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Does Mutation of Transforming Growth Factor-β Type II Receptor Gene Play an Important Role in Colorectal Polyps?

Digestive Diseases and Sciences volume 44, pages 1803–1809 (1999)Cite this article

Abstract

Mutations in the transforming growthfactor-β type II receptor (RII) gene that remainuncorrected due to mutation and inactivation of mismatchrepair genes play an important role in hereditarynonpolyposis colorectal cancer (HNPCC) and in a subset ofsporadic colorectal cancers. Some colorectal cancersdevelop from colorectal polyps. To elucidate the role ofthe RII gene in the generation of colorectal polyps, we analyzed 137 colorectal polyps from 100patients for RII mutations and microsatelliteinstability (MSI). MSI was detected in three of 36polyps from 25 patients. For one of these three polyps,the mobilities of the PCR products between polyp and nonpolyptissues was different for only one microsatellitemarker, and for the other two polyps the mobilities weredifferent for more than two markers. These two polyps were obtained from one patient with ascendingcolon carcinoma and suspected HNPCC based on hisclinical profile and family history. An RII mutation wasdetected in only one of these two polyps. RII may play a minor role in sporadic colorectalpolyps. RII gene analysis in colorectal polyps may be auseful screening measure for potential HNPCCpatients.

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Authors
  1. Goichi Togo
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  2. Makoto Okamoto
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  3. Yasushi Shiratori
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  4. Hiroshi Yamaji
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  5. Jun Kato
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  6. Masayuki Matsumura
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  7. Takaaki Sano
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  8. Teiji Motojima
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  9. Masao Omata
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Togo, G., Okamoto, M., Shiratori, Y. et al. Does Mutation of Transforming Growth Factor-β Type II Receptor Gene Play an Important Role in Colorectal Polyps?. Dig Dis Sci 44, 1803–1809 (1999). https://doi.org/10.1023/A:1018834404570

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  • DOI: https://doi.org/10.1023/A:1018834404570

  • COLORECTAL POLYP
  • MICROSATELLITE INSTABILITY
  • HEREDITARY NONPOLYPOSIS COLORECTALCANCER
  • MISMATCH REPAIR GENE
  • TRANSFORMING GROWTH FACTOR-β TYPE IIRECEPTOR