Abstract
Manometric assessment of the diaphragmaticcontribution to the human gastroesophageal barrier isdifficult because it overlaps with that of the loweresophageal sphincter. Our aim was to investigate the barrier components in the rat in which thegastroesophageal junction is widely separated from thehiatus. Rats under anesthesia (N = 119) and after musclerelaxation (N = 14) underwent stationary andpull-through perfusion manometry. Inspiratorytransdiaphragmatic pressure gradient was 5.79 ±1.69 mm Hg and lower esophageal sphincter pressure was14.76 ± 8.63 mm Hg. A 13.78 ± 3.13-mmintraabdominal segment of the esophagus was interposed craniallybetween the sphincter and a group of phasic oscillationswith frequency identical to the respiratory rate andpressure of 13.81 ± 6.54 mm Hg, which disappeared after muscle relaxation. Both components of thegastroesophageal barrier in the rat are widely separatedby a long intraabdominal esophagus. This arrangementallows investigation of the behavior of both components under challengingconditions.
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Soto, C., Qi, B., Diez-Pardo, J.A. et al. Identification of Diaphragmatic Crural Component of Gastroesophageal Barrier in the Rat. Dig Dis Sci 42, 2420–2425 (1997). https://doi.org/10.1023/A:1018831705342
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DOI: https://doi.org/10.1023/A:1018831705342