Digestive Diseases and Sciences

, Volume 43, Issue 6, pp 1165–1171 | Cite as

Effect of Capsaicin-Containing Red Pepper Sauce Suspension on Upper Gastrointestinal Motility in Healthy Volunteers

  • R. Gonzalez
  • R. Dunkel
  • B. Koletzko
  • V. Schusdziarra
  • H. D. Allescher


Afferent nerves play a major role in theregulation of gastrointestinal motility. The questionsremains if specific food ingredients can selectivelyactivate such fibers. The aim of the study was toinvestigate the effect of intraesophageal application of acapsaicin-containing red pepper sauce (Tabasco)suspension on upper gastrointestinal motility in acontrolled trial. After a baseline recording [esophageal motility, balloon distension, electrogastrogram(EGG)], red pepper or saline solution was infusedintraesophageally in seven healthy volunteers. At 30 mingastric emptying and orocecal transit time were determined using a [13C]acetate andH-lactulose breath test. Infusion of red pepper saucesuspension signifi2 cantly increased the amplitudes(65.8 ± 3 to 78.5 ± 4.7 mm Hg, P <0.05) and propagation velocity (2.9 ± 0.3 to 4.25 ± 0.3sec, P < 0.05) of esophageal pressure waves and LESpressure (17.8 ± 1.4 to 23.7 ± 2.6 mm Hg,P < 0.05). It significantly decreased perception anddiscomfort threshold of intraesophageal balloondistension, reduced the percentage of normal electricalactivity in the EGG, and delayed gastric emptying(saline: T1/2 42.9 ± 12.0 min vs redpepper: T1/2 66.8 ± 19.0 min, P < 0.05). Despite theprolongation of gastric emptying, orocecal transit timewas not altered, indicating an actual increase ofintestinal transit. Esophageal application ofcapsaicin-containing red pepper sauce suspension had profoundchanges on upper gastrointestinal motility, which couldimprove clearance and protection of the esophagus andcould lead to retention of the irritant in the stomach and faster transit through the smallbowel.



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Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • R. Gonzalez
  • R. Dunkel
  • B. Koletzko
  • V. Schusdziarra
  • H. D. Allescher

There are no affiliations available

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