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Effects of Rebamipide, a Novel Anti-Ulcer Agent, on Gastric Mucosal Injury Induced by Platelet-Activating Factor in Rats

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Abstract

We examined the role of gastric mucosal bloodflow, lipid peroxidation, and neutrophil accumulationmediated by platelet-activating factor in the protectiveeffect of rebamipide against gastric mucosal injury in rats. The intravenous injection ofplatelet-activating factor induced hyperemia andhemorrhagic erosions in rat stomachs. Rebamipide did notaffect the decrease in the gastric mucosal blood flow induced by platelet-activating factor. Theincrease in gastric injury score afterplatelet-activating factor injection and the increase inthiobarbituric acid-reactive substances weresignificantly inhibited by the administration of rebamipide. Thegastric injury score was closely correlated with theaccumulation of lipid peroxides. Tissue-associatedmyeloperoxidase activity in the gastric mucosasignificantly increased after platelet activating factorinjection; this increase was not influenced byrebamipide treatment. The protective effect ofrebamipide against the platelet-activitingfactor-induced gastric mucosal injury may be due to direct inhibitionof lipid peroxidation or scavenging of oxygen radicalsthat initiate lipid peroxidation.

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Authors
  1. Satoshi Kokura
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  2. Toshikazu Yoshikawa
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  3. Yuji Naito
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  4. Hiroshi Ichikawa
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  5. Hirohisa Takano
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  6. Shuji Takahashi
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  7. Takashi Tomii
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  8. Norimasa Yoshida
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  9. Motoharu Kondo
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Kokura, S., Yoshikawa, T., Naito, Y. et al. Effects of Rebamipide, a Novel Anti-Ulcer Agent, on Gastric Mucosal Injury Induced by Platelet-Activating Factor in Rats. Dig Dis Sci 42, 2566–2571 (1997). https://doi.org/10.1023/A:1018829032175

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