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Delayed Gastric Emptying by Helicobacter pylori Lipopolysaccharide in Conscious Rats

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Abstract

The present study was carried out to investigatethe possibility that lipopolysaccharide deprived fromHelicobacter pylori may alter gastric motility. Toaddress the question, we examined the effect of H. pylori lipopolysaccharide on gastricemptying in conscious rats. Gastric emptying wasevaluated by the phenol red method. Time-course anddose-related effects of intraperitoneal administrationof H. pylori lipopolysaccharide were investigated.Intraperitoneal injection of H. pylorilipopolysaccharide significantly suppressed gastricemptying of a liquid meal in a dose-dependent manner.The inhibitory action of H. pylori lipopolysaccharide wasobserved 2, 4, 8, or 12 hr after the injection. Theseresults suggest for the first time that H. pylorilipopolysaccharide may suppress gastric emptying in along-lasting fashion. It is also suggested that H. pylorimay influence gastric function through its cell wallstructure named lipopolysaccharide.

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Authors
  1. Toshikatsu Okumura
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  2. Etsuro Shoji
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  3. Nobuhiko Takahashi
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  4. Hirokazu Wakebe
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  5. Kenichi Imagawa
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  6. Mikio Kikuchi
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  7. Yutaka Kohgo
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Okumura, T., Shoji, E., Takahashi, N. et al. Delayed Gastric Emptying by Helicobacter pylori Lipopolysaccharide in Conscious Rats. Dig Dis Sci 43, 90–94 (1998). https://doi.org/10.1023/A:1018828105226

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