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Central Administration of PACAP Stimulates Gastric Secretion Mediated Through the Vagal Pathway in Anesthetized Rats

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Abstract

Pituitary adenylate cyclase activatingpolypeptide (PACAP) is a neuropeptide that wasoriginally isolated from ovine hypothalamic tissue. Thepeptide has two amidated forms, PACAP38 and PACAP27. Inthis study, we examined the effects of centrallyadministered PACAP38 and PACAP27 on gastric secretion inanesthetized rats. Centrally administered PACAPstimulated gastric acid and pepsin secretion in adose-dependent manner. PACAP38 was 1.5-2 times more potentthan PACAP27 on gastric secretion. By contrast,intravenously administered PACAP38 had no effect onbasal or pentagastrin-stimulated gastric secretion.PACAP6-38, a PACAP antagonist, by itself at high dosesalso stimulated gastric and pepsin secretion, but atlower doses had no effect. Centrally administeredPACAP6-38 at a dose that had no effect on gastricsecretion, atropine pretreatment, or vagotomypretreatment, suppressed the stimulatory effect ofPACAP38. It is concluded that centrally administeredPACAP may have a regulatory effect on gastric secretionthrough PACAP receptors and the vagalpathway.

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Authors
  1. Makoto Ozawa
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  2. Mitsuru Aono
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  3. Kazuhiko Mizuta
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  4. Motoyuki Moriga
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  5. Minoru Okuma
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Ozawa, M., Aono, M., Mizuta, K. et al. Central Administration of PACAP Stimulates Gastric Secretion Mediated Through the Vagal Pathway in Anesthetized Rats. Dig Dis Sci 42, 2552–2559 (1997). https://doi.org/10.1023/A:1018824931267

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