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Pharmacologic Characteristics of Rabbit Esophageal Muscularis Mucosae In Vitro

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Abstract

The aim of this study was to investigate invitro the pharmacologic properties of rabbit esophagealmuscularis mucosae. Stimulation of its motor innervationelicited only atropinesensitive excitatory responses. This tissue was not refractory to histamine butappeared to be rapidly desensitized to its effects.Responses to adrenoreceptor agonists were produced byexcitatory α1 and β1adrenoreceptors, inhibitory β3 receptors but notα2 receptors. The esophageal muscularismucosae was only weakly stimulated by neurokinins andbradykinin, and these responses were mediated via NK2,NK3, B1, and B2 receptors, respectively. Adenosine diphosphate andadenosine triphosphate produced ≈40% maximalcontractions through the activation of P2 receptors,whereas adenosine monophosphate and adenosine werewithout effect. Responses to prostaglandins E2 andF2α were ≤10% of the tissues'maximum response to acetylcholine. These datademonstrate that rabbit esophageal muscularis mucosaehas a simple excitatory innervation and is only weaklystimulated by a variety of pharmacologic agents. For thesereasons it is distinct from muscularis mucosae foundelsewhere in the rabbit gastrointestinaltract.

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Authors
  1. W. H. Percy
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  2. A. J. Miller
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  3. J. T. Brunz
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Percy, W.H., Miller, A.J. & Brunz, J.T. Pharmacologic Characteristics of Rabbit Esophageal Muscularis Mucosae In Vitro. Dig Dis Sci 42, 2537–2546 (1997). https://doi.org/10.1023/A:1018820830358

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