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Programmed Cell Death in the Terminal Endbud

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Abstract

Ductal development in the pubertal mouse mammarygland is characterized by dramatic morphological changesin the epithelium driven by proliferation of cap andbody cells in the terminal endbuds. Recent experiments revealed a coincident and abundantapoptosis in the body cells of these structures. Thecells undergoing apoptosis are occasionally restrictedto defined regions within the terminal endbud. Localization adjacent to the presumptive luminasuggests that this process functions to sculpt thelumina of the subtending duct. Members of the Bcl-2family of apoptosis regulatory molecules; Bcl-2 and Bcl-x, appear to have some role in regulatingapoptosis in the terminal endbud. Other possible signalswhich could regulate this developmental process and amodel are presented.

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  1. Robin C. Humphreys
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Humphreys, R.C. Programmed Cell Death in the Terminal Endbud. J Mammary Gland Biol Neoplasia 4, 213–220 (1999). https://doi.org/10.1023/A:1018733426625

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