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Evaluation of in vitro bioactivity and biocompatibility of Bioglass®-reinforced polyethylene composite


The bioactivity and biocompatibility of Bioglass®-reinforced high-density polyethylene composite (Bioglass®/HDPE) have been evaluated in simulated body fluid (SBF) and by in vitro cell culture, respectively. The formation of a biologically active hydroxy-carbonate apatite (HCA) layer on the composite surface after immersion in SBF was demonstrated by thin-film X-ray diffraction, infrared spectroscopy and scanning electron microscopy, indicating the in vitro bioactivity of Bioglass®/HDPE composites. The HCA layer was formed on the 40 vol% composite surface within 3 days immersion in SBF at a formation rate comparable to those on bioactive glass-ceramics, showing that in vitro bioactivity could be obtained in a composite. Furthermore, the composite was biocompatible to primary human osteoblast-like cells. In comparison with unfilled HDPE and tissue culture plastic control, a significant increase in cellular metabolic activity was found on the composite. Therefore, Bioglass®/HDPE composites have a promising biological response as a potential implant material.

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HUANG, J., SILVIO, L.D., WANG, M. et al. Evaluation of in vitro bioactivity and biocompatibility of Bioglass®-reinforced polyethylene composite. Journal of Materials Science: Materials in Medicine 8, 809–813 (1997).

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  • Apatite
  • Simulated Body Fluid
  • HDPE
  • Composite Surface
  • Tissue Culture Plastic