The bioactivity and biocompatibility of Bioglass®-reinforced high-density polyethylene composite (Bioglass®/HDPE) have been evaluated in simulated body fluid (SBF) and by in vitro cell culture, respectively. The formation of a biologically active hydroxy-carbonate apatite (HCA) layer on the composite surface after immersion in SBF was demonstrated by thin-film X-ray diffraction, infrared spectroscopy and scanning electron microscopy, indicating the in vitro bioactivity of Bioglass®/HDPE composites. The HCA layer was formed on the 40 vol% composite surface within 3 days immersion in SBF at a formation rate comparable to those on bioactive glass-ceramics, showing that in vitro bioactivity could be obtained in a composite. Furthermore, the composite was biocompatible to primary human osteoblast-like cells. In comparison with unfilled HDPE and tissue culture plastic control, a significant increase in cellular metabolic activity was found on the composite. Therefore, Bioglass®/HDPE composites have a promising biological response as a potential implant material.
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L. L. HENCH, J. Amer. Ceram. Soc. 74 (1991) 1487
W. BONFIELD, M. D. GRYNPAS, A. E. TULLY, J. BOWMAN, J. ABRAM, Biomaterials 2 (1981) 185.
P. DUCHEYNE and L. L. HENCH, J. Mater. Sci. 17 (1982) 595.
M. WANG, W. BONFIELD and L. L. HENCH, Bioceramics 8 (1995) 383.
R. L. OREFICE, G. P. LATORRE, J. K. WEST and L. L. HENCH, ibid. 8 (1995) 409.
W. BONFIELD, C. DOYLE and K. E. TANNER, in “Biological and Biomechanical Performance of Biomaterials”, edited by P. Cristel, A. Meunier and A. J. C. Lee (Elsevier, Amsterdam, 1986) p. 153.
P. DUCHEYNE, M. MARCOLONGO and E. SCHEPERS, in “An Introduction to Bioceramics” edited by L. L. Hench and J. Wilson (World Scientific, Singapore, 1993) p. 281.
J. TAMNRA, K. KAWANABE, M. KOBAYASHI, T. NAKAMURA, T. KOKUBO, S. YOSHIHARA and T. SHIBUYA, J. Biomed. Mater. Res. 30 (1996) 85.
T. KITSUGI, T. YAMAMURO, T. NAKAMURA, S. HIGASHI, Y. KAKUTANI, K. HYAKUNA, S. ITO, T. KOKUBO, M. TAKAGI and T. SHIBUYA, ibid. 20 (1986) 1295.
T. KOKUBO, H. KUSHITANI, S. SAKKA, T. KITSUGI and T. YAMAMURO, ibid. 24 (1990) 721.
L. L. HENCH and G. P. LATORRE, Bioceramics 5 (1992) 67.
M. R. FILGUEIRAS, G. LATORRE and L. L. HENCH, J. Biomed. Mater. Res. 27 (1993) 445.
C. OHTSUKI, Y. AOKI, T. KOKUBO, Y. BANDO, M. NEO and T. NAKAMURA, J. Ceram. Soc. Jpn 103 (1995) 449.
U. GROSS, H. J. SCHMITZ, R. KINNE, F. R. FENDLER and V. STRUNZ, in “Biomaterials and Clinical Application”, edited by A. Pizzoferrato, P. G. Marchetti, A. Ravaglioli and A. J. C. Lee (Elsevier, Amsterdam, 1987) p. 547.
A. EI-GHANNAM, P. DUCHEYNE and I. SHAPIRO, Bioceramics 6 (1993) 143.
W. C. A. VROUWENVELDER, C. G. GROOT and K. DE GROOT, Biomaterials 13 (1992) 382.
L. DI SILVIO, PhD thesis, University of London (1995).
A. A. IGNATIUS and L. E. CLAES, Biomaterials 17 (1996) 831.
C. J. CLIFFORD and S. DOWNES, J. Mater. Sci. Mater. Med. 7 (1996) 637.
J. HUANG, M. WANG, I. REHMAN, J. KNOWLES and W. BONFIELD, Bioceramics 8 (1995) 389.
T. YAMAMURO, in “An Introduction to Bioceramics” edited by L. L. Hench and J. Wilson (World Scientific, Singapore, 1993) p 89.
O. H. ANDERSSON, J. ROSENQVIST and K. H. KARLSSON, J. Biomed. Mater. Res. 27 (1993) 941.
L. L. HENCH, Bioceramics 7 (1994) 3.
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HUANG, J., SILVIO, L.D., WANG, M. et al. Evaluation of in vitro bioactivity and biocompatibility of Bioglass®-reinforced polyethylene composite. Journal of Materials Science: Materials in Medicine 8, 809–813 (1997). https://doi.org/10.1023/A:1018581100400
- Simulated Body Fluid
- Composite Surface
- Tissue Culture Plastic