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Bioactivity of sol–gel derived organically modified silicates: Part I: In vitro examination

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Abstract

Bioactivity was investigated for several organically modified silicates (Ormosils) prepared through sol–gel processes. Ca(II)-free samples were biocompatible only, but Ca(II)containing samples were bioactive and deposited apatite during immersion in a simulated body fluid. The ease of silanol (Si–OH) group formation on the ormosils was considered a predominant factor controlling the bioactivity, while the effect of dissolved Ca(II) ions to increase the degree of supersaturation in the simulated body fluid is secondary.

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Authors and Affiliations

  1. Biomaterials Division, Faculty of Engineering, Okayama University Tsushima, Okayama-shi, 700, Japan

    K TSURU

  2. Materials Department, School of Applied Science and Engineering, University of California, Los Angeles, CA, 90024, USA

    C OHTSUKI

Authors
  1. K TSURU
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  2. C OHTSUKI
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  3. A OSAKA
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  4. T IWAMOTO
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  5. J. D MACKENZIE
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TSURU , K., OHTSUKI , C., OSAKA , A. et al. Bioactivity of sol–gel derived organically modified silicates: Part I: In vitro examination. Journal of Materials Science: Materials in Medicine 8, 157–161 (1997). https://doi.org/10.1023/A:1018523203667

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  • DOI: https://doi.org/10.1023/A:1018523203667

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