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The effect of fumonisin B1 on the growth of bacteria

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Abstract

Fumonisins are mycotoxins produced by several Fusarium species which are common contaminants of maize and maize products. Their toxicity and carcinogenicity for animals ingesting these toxins have been clearly demonstrated, but, there are no studies on the effect of fumonisins on bacteria. In this study various Gram-positive and Gram-negative bacteria including typical representatives of the human intestinal flora were grown in the presence of 50 to 1000 μM fumonisin B1 and the fumonisin concentrations in the culture medium were determined after incubation for a certain period. No inhibition of bacterial growth was observed, indicating that this mycotoxin is non-toxic for the bacteria investigated. There was no indication that fumonisin B1 was metabolized by the bacteria as its concentration in the culture medium did not decrease during the incubation period.

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References

  • Cawood, M.E., Gelderblom, W.C.A., Vleggaar, R., Behrend, Y., Thiel, P.G. & Marasas, W.F.O. 1991 Isolation of the fumonisin toxins: a quantitative approach. Journal of Agricultural and Food Chemistry 39, 1958-1962.

    Google Scholar 

  • Gelderblom, W.C.A., Jaskiewicz, K., Marasas, W.F.O., Thiel, P.G., Horak, R.M., Vleggaar, R. & Kriek, N.P.J. 1988 Fumonisins-Novel mycotoxins with cancer-promoting activity produced by Fusarium moniliforme. Applied and Environmental Microbiology 54, 1806-1811.

    PubMed  Google Scholar 

  • Gelderblom, W.C.A., Kriek, N.P.J., Marasas, W.F.O. & Thiel, P.G. 1991 Toxicity and carcinogenicity of the Fusarium moniliforme metabolite, fumonisin B1, in rats. Carcinogenesis 12, 1247-1251.

    PubMed  Google Scholar 

  • Kaneshiro, T., Vesonder, R.F., Peterson, R.E. 1992 Fumonisinstimulated N-acetyl dihydrosphingosine, and phytosphingosine products of Pichia (Hansenula) ciferri, NRRL Y-1031. Current Microbiology 24, 319-324.

    Google Scholar 

  • Kaneshiro, T., Vesonder, R.F., Peterson, R.E. & Bagby, M.O. 1993 2-Hydroxyhexadecanoic and 8,9,13-Trihydroxydocosanoic acid accumulation by yeasts treated with fumonisin B1. Lipids 28, 397-401.

    PubMed  Google Scholar 

  • Kellerman, T.S., Marasas, W.F.O., Thiel, P.G., Gelderblom, W.C.A., Cawood, M.E. & Coetzer, J.A.W. 1990 Leukoencephalomalacia in two horses induced by oral dosing of fumonisin B1. Onderstepoort Journal of Veterinary Research 57, 269-275.

    PubMed  Google Scholar 

  • Madhyastha, M.S., Marquardt, R.R., Masi, A., Borsa, J. & Frohlich, A.A. 1994 Comparison of toxicity of different mycotoxins to several species of bacteria and yeasts: use of Bacillus brevis in a disc diffusion assay. Journal of Food Protection 57, 48-53.

    Google Scholar 

  • Marasas, W.F.O., Kellerman, T.S., Gelderblom, W.C.A., Coetzer, J.A.W., Thiel, P.G. & van der Lugt, J.J. 1988 Leukoencephalomalacia in a horse induced by fumonisin B1, isolated from Fusarium moniliforme. Onderstepoort Journal of Veterinary Research 55, 197-203.

    PubMed  Google Scholar 

  • Marasas, W.F.O., Shephard, G.S., Sydenham, E.W. & Thiel, P.G. 1993 World-wide contamination of corn with fumonisins: food-borne carcinogens produced by Fusarium moniliforme. Proceedings of the International Cereal Chemistry Conference, Pretoria, South Africa.

  • Mattila, T. 1987 Automated turbidometry-A method for enumeration of bacteria in food samples. Journal of Food Protection 50, 640-642.

    Google Scholar 

  • Nelson, P.E., Plattner, R.D., Shackelford, D.D. & Desjardins, A.E. 1992 Fumonisin B1 production by Fusarium species other than F. moniliforme in section Liseola. Applied and Environmental Microbiology. 58, 984-989.

    PubMed  Google Scholar 

  • Ross, P.F., Nelson, P.E., Richard, J.L., Osweiler, G.D., Rice, L.G., Plattner, R.D. & Wilson, T.M. 1990 Production of fumonisins by Fusarium moniliforme and Fusarium proliferatum isolates associated with equine leukoencephalomalacia and a pulmonary edema syndrome in swine. Applied and Environmental Microbiology 56, 3225-3226.

    PubMed  Google Scholar 

  • Rheeder, J.P., Marasas, W.F.O., Thiel, P.G., Sydenham, E.W., Shephard, G.S. & Van Schalkwyk, D.J. 1992 Fusarium moniliforme and fumonisins in corn in relation to human esophageal cancer in Transkei. Phytopathology 82, 353-357.

    Google Scholar 

  • Skyttä, E. & Mattila-Sandholm, T. 1991 A quantitative method for assessing bacteriocins and other food antimicrobials by automated turbidometry. Journal of Microbiological Methods 14, 77-88.

    Google Scholar 

  • Stanier, R.Y., Adelberg, E.A. & Ingraham, J.L. 1979 Microbial growth. In General Microbiology, fourth edn. pp. 275-292. London and Basingstoke: Macmillan Press.

    Google Scholar 

  • Sydenham, E.W., Marasas, W.F.O., Shephard, G.S., Thiel, P.G. & Hirooka, E.Y. 1992a Fumonisin contamination of Brazilian feeds associated with field outbreaks of confirmed and suspected animal mycotoxicoses. Journal of Agricultural Food Chemistry 40, 994-997.

    Google Scholar 

  • Sydenham, E.W., Shephard, G.S. & Thiel, P.G. 1992b Liquid chromatographic determination of fumonisins B1, B2, and B3 in foods and feeds. Journal of the Association of Official Analytical Chemistry International 75, 313-318.

    Google Scholar 

  • Sydenham E.W., Shephard, G.S., Thiel, P.G., Marasas, W.F.O. & Stockenström, S. 1991 Fumonisin contamination of commercial corn-based human foodstuffs. Journal of Agricultural and Food Chemistry 39, 2014-2018.

    Google Scholar 

  • Sydenham E.W., Shephard, G.S., Thiel, P.G., Marasas, W.F.O., Rheeder, J.P., Peralta Sanhueza, C.E., Gonzales, H.H.L. & Resnik, S.L. 1993 Fumonisins in Argentinian field-trial corn. Journal of Agricultural and Food Chemistry 41, 891-895.

    Google Scholar 

  • Thiel, P.G., Marasas, W.F.O., Sydenham, E.W., Shephard, G.S., Gelderblom, W.C.A. & Nieuwenhuis, J.J. 1991 Survey of fumonisin production by Fusarium species. Applied and Environmental Microbiology 57, 1089-1093.

    PubMed  Google Scholar 

  • Thiel, P.G., Marasas, W.F.O., Sydenham, E.W., Shephard, G.S., & Gelderblom, W.C.A. 1992 The implications of naturally occurring levels of fumonisins in corn for human and animal health. Mycopathologia 117, 3-9.

    PubMed  Google Scholar 

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Becker, B., Bresch, H., Schillinger, U. et al. The effect of fumonisin B1 on the growth of bacteria. World Journal of Microbiology and Biotechnology 13, 539–543 (1997). https://doi.org/10.1023/A:1018513308847

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