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Technetium-99m nitride radiopharmaceuticals

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Abstract

Following the introduction of an efficient method for the preparation of technetium-99m complexes containing a terminal Tc-N multiple bond, under conditions suitable for nuclear medicine applications, new radiopharmaceuticals for heart and brain imaging have been discovered. These compounds belong to the class of bi-substituted, square-pyramidal nitride TcV complexes with dithiocarbamate ligands, and are the first examples of radiopharmaceuticals of this type exhibiting interesting biological properties. The peculiar chemical characteristics of the Tc-N core can also be conveniently utilized for the design of radiopharmaceuticals incorporating bioactive peptides and having definite structural features.

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Authors and Affiliations

  1. Dipartimento di Chimica Fisica ed Inorganica, Universita` di Bologna, Viale Risorgimento, 4, 40136, Bologna, Italy

    Adriano Duatti

  2. Dipartimento di Medicina Clinica e Sperimentale, Universita` di Ferrara, Via L. Borsari, 46, 44100, Ferrara, Italy

    Cristina Bolzati & Licia Uccelli

  3. Dipartimento di Chimica, Universita` di Ferrara, Via L. Borsari, 46, 44100, Ferrara, Italy

    Gian Luigi Zucchini

Authors
  1. Adriano Duatti
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  2. Cristina Bolzati
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  3. Licia Uccelli
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  4. Gian Luigi Zucchini
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Duatti, A., Bolzati, C., Uccelli, L. et al. Technetium-99m nitride radiopharmaceuticals. Transition Metal Chemistry 22, 313–314 (1997). https://doi.org/10.1023/A:1018489113564

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