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Serum steroids in relation to prostate cancer risk in a case-control study (Greece)

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Abstract

Blood samples were collected from 52 incident cases of histologicallyconfirmed prostate cancer and 52 age- and town of residence-matched healthycontrols in Athens, Greece. Samples were analyzed blindly in Boston,Massachusetts (USA) for testosterone (T), estradiol (E2), sex hormone-bindingglobulin (SHBG), and dihydrotestosterone (DHT). The data were modeled usingmultiple logistic regression with adjustment for age, height, body mass index(wt/ht2), years of schooling, and mutually among hormones. DHT was associatedinversely, significantly, and strongly with the risk of prostate cancer,whereas T was associated marginally positively, and E2 was associatednonsignificantly inversely with the disease. No association was observed inthis study with respect to SHBG.

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Authors and Affiliations

  1. Department of Epidemiology and Harvard Center for Cancer Prevention, Harvard School of Public Health, Boston, USA

    Lisa B. Signorello, Christos S. Mantzoros, Loren Lipworth, Pagona Lagiou, Meir Stampfer & Dimitrios Trichopoulos

  2. Department of Hygiene and Epidemiology, University of Athens Medical School, Goudi Athens, USA

    Anastasia Tzonou

  3. Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA

    Christos S. Mantzoros

  4. Department of Nutrition and Biochemistry, National School of Public Health, Athens, USA

    Pagona Lagiou

  5. Cancer Center, University of Massachusetts Medical Center, Worcester, USA

    Chung-cheng Hsieh

Authors
  1. Lisa B. Signorello
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  2. Anastasia Tzonou
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  3. Christos S. Mantzoros
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  4. Loren Lipworth
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  5. Pagona Lagiou
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  6. Chung-cheng Hsieh
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  7. Meir Stampfer
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  8. Dimitrios Trichopoulos
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Signorello, L.B., Tzonou, A., Mantzoros, C.S. et al. Serum steroids in relation to prostate cancer risk in a case-control study (Greece). Cancer Causes Control 8, 632–636 (1997). https://doi.org/10.1023/A:1018454632045

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  • DOI: https://doi.org/10.1023/A:1018454632045

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