Cancer Causes & Control

, Volume 8, Issue 4, pp 615–625 | Cite as

Serum levels of vitamin D metabolites and the subsequent risk of colon and rectal cancer in Finnish men

  • Joseph Tangrea
  • Kathy Helzlsouer
  • Pirjo Pietinen
  • Philip Taylor
  • Bruce Hollis
  • Jarmo Virtamo
  • Demetrius Albanes
Article

Abstract

Experimental and human epidemiologic data suggest a protective rolefor vitamin D in large bowel cancer. To investigate this association, weconducted a nested case-control study within a Finnish clinical trial cohort.Cases (n = 146) were participants diagnosed with primary adenocarcinoma ofthe large bowel. Controls were matched (2:1) to cases on age, date ofbaseline blood draw, and study clinic. Prediagnostic serum levels of thevitamin D metabolites, 25-hydroxyvitamin D (25-OH D), and1,25-dihydroxyvitamin D (1,25-DIOHD) were used as primary exposure measures.The baseline geometric-mean serum level of 25-OH D was 11.6 percent lower incases than in controls (12.2 cf 13.8 ug/l, P = 0.01) while serum levels of1,25-DIOH D did not differ by case-control status. No association was seenbetween serum levels of 1,25-DIOH D and large bowel cancer risk. However, theestimated relative risk (RR) of large bowel cancer decreased with increasinglevel of serum 25-OH D and the associa tion was more pronounced for rectalcancer (55 cases; RR by quartile = 1.00, 0.93, 0.77, 0.37; trend P = 0.06).Neither exclusion of early cases nor multivariate adjustment for potentialconfounders materially altered these estimates. There was no evidence ofeffect modification by level of 1,25-dihydroxyvitamin D or with other knownrisk-factors for large bowel cancer.

25-hydroxyvitamin D colorectal cancer Finland men rectal cancer vitamin D 

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Copyright information

© Chapman and Hall 1997

Authors and Affiliations

  • Joseph Tangrea
    • 1
  • Kathy Helzlsouer
    • 2
  • Pirjo Pietinen
    • 3
  • Philip Taylor
    • 1
  • Bruce Hollis
    • 4
  • Jarmo Virtamo
    • 1
  • Demetrius Albanes
    • 1
  1. 1.National Cancer Institute, NIHBethesdaUSA
  2. 2.School of Hygiene and Public HealthJohns Hopkins UniversityctyBaltimoreUSA
  3. 3.National Public Health InstituteHelsinkiUSA
  4. 4.Medical University of South CarolinaCharlestonUSA

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