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Rhodium-105 complexes as potential radiotherapeutic agents

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Abstract

Rhodium-105 complexes have been investigated for their suitability as the basis of potential bifunctional chelating agents for therapeutic radiopharmaceuticals. Rhodium-105 is a reactor-produced therapeutic radionuclide that is available in high specific activity. The chemistry and biology of several six-coordinate Rh(III) complexes of the general form [RhCl2L]+, where L is a tetradentate ligand containing at least three thioethers donor atoms, is discussed. The backbone chain length of the acyclic or macrocyclic ligand determines the geometry about the Rh(III) centre (cis vs. trans), with the larger ligands preferentially forming trans-dichloro complexes. The stability of all of the 105Rh complexes is very high (>5 days) and the biological clearance properties of the complexes are consistent with their relative lipophilicities.

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Authors and Affiliations

  1. Chemistry Department, University of Missouri, Columbia, MO, 65211, USA

    Silvia S. Jurisson

  2. MU Research Reactor, University of Missouri, Columbia, MO, 65211, USA

    Alan R. Ketring

  3. Radiology Department, University of Missouri, Columbia, MO, 65211, USA

    Wynn A. Volkert

Authors
  1. Silvia S. Jurisson
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  2. Alan R. Ketring
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  3. Wynn A. Volkert
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Jurisson, S.S., Ketring, A.R. & Volkert, W.A. Rhodium-105 complexes as potential radiotherapeutic agents. Transition Metal Chemistry 22, 315–317 (1997). https://doi.org/10.1023/A:1018441230403

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