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Kinetic study of enantioselective esterification of ketoprofen with n-propanol catalysed by an lipase in an organic medium

Biotechnology Letters volume 19, pages 1051–1055 (1997)Cite this article

Abstract

A kinetic study of an immobilised lipase esterification reaction in dipropyl ether for resolution of ketoprofen indicated a Bi Bi Ping Pong mechanism with dead-end inhibition of the alcohol was occurring for both enantiomers and this is was confirmed experimentally. Parameters in the kinetic equation and reaction activation energies for the two enantiomers were determined by non-linear regression.

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Authors and Affiliations

  1. Department of Chemical Engineering, The National University of Singapore, 10 Kent Ridge Crescent, Singapore, 119260

    G. Duan, C.B. Ching, E. Lim & C.H. Ang

Authors
  1. G. Duan
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  2. C.B. Ching
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  3. E. Lim
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  4. C.H. Ang
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Duan, G., Ching, C., Lim, E. et al. Kinetic study of enantioselective esterification of ketoprofen with n-propanol catalysed by an lipase in an organic medium. Biotechnology Letters 19, 1051–1055 (1997). https://doi.org/10.1023/A:1018420022398

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  • DOI: https://doi.org/10.1023/A:1018420022398

Keywords

  • Alcohol
  • Ether
  • Activation Energy
  • Organic Chemistry
  • Lipase