Cancer Causes & Control

, Volume 8, Issue 3, pp 473–490 | Cite as


  • Aaron Blair
  • Neely Kazerouni


Epidemiologic evidence on the relation between reactive chemicals and cancer is reviewed. These highly reactive chemicals (acrylonitrile; bis[chloromethyl]ether and chloromethyl methyl ether; 1,3-butadiene, ethylene oxide; formaldehyde; mustard gas; sulfuric acid; and vinyl chloride) vary in use and exposure. All are animal carcinogens that also have received considerable epidemiologic attention. Acrylonitrile is a chemical of current economic importance. The epidemiologic evidence is quite weak, but the available studies were very small. Epidemiologic studies clearly demonstrate that bis (chloromethyl) ether and chloromethyl methyl ether cause lung cancer. Continued follow-up of exposed workers is encouraged to provide information on risks for other cancers. Results from epidemiologic studies of butadiene-exposed workers are somewhat inconsistent, but the largest study with the best exposure assessment found the largest relative risk for leukemia. The failure of several larger studies to replicate the early Swedish findings of a very strong association between leukemia and ethylene oxide has not been adequately explained. Epidemiologic studies of formaldehyde provide limited evidence for an association with cancer of the nasopharynx and possibly with nasal cancer. These very rare tumors, however, are difficult to study epidemiologically. Mustard gas is a well-established lung carcinogen, but a recent follow-up of the English cohort suggests that other sites also maybe affected. Sulfuric acid appears to cause laryngeal cancer. A suggested relationship with lung cancer in a few studies is of concern because of the widespread opportunity for exposure from ambient air pollution. Vinyl chloride causes angiosarcoma of the liver, but a large, multi-country study provided no clear evidence that other sites are affected.

Cancer reactive chemicals 


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  1. 1.
    Verschueren K. Handbook of Environmental Data on Organic Chemicals. New York, NY (USA): Van Nostrand Reinhold, 1983: 162.Google Scholar
  2. 2.
    International Agency for Research on Cancer. Overall Evaluations of Carcinogenicity: an Updating of IARC Monographs Volumes 1 to 42. Lyon, France: IARC, 1987; IARC Monogr Eval Carcinog Risks Humans. Google Scholar
  3. 3.
    Rothman KJ. Cancer occurrence among workers exposed to acrylonitrile. Scand J Work Environ Health 1994; 20: 313–21.Google Scholar
  4. 4.
    World Health Organization. Acrylonitrile. Geneva, Switzerland: WHO, 1983.Google Scholar
  5. 5.
    Roberts AE, Kedderis GL, Turner MJ, Rickert DE, Swen-berg JA. Species comparison of acrylonitrile epoxidation by microsomes from mice, rats, and humans: relationship to epoxide concentrations in mouse and rat blood. Car-cinogenesis 1991; 12: 401–4.Google Scholar
  6. 6.
    Lambotte M, Duverger M, Garny V, Poncelet F, Mercier M. Mutagenicity of metabolites of acrylonitrile detected in urine. Mutat Res 1981; 85: 269.Google Scholar
  7. 7.
    Osterman-Golkar SM, MacNeela JP, Turner MJ, et al. Monitoring exposure to acrylonitrile using adducts with N-terminal valine in hemoglobin. Carcinogenesis 1994; 15: 2701–7.Google Scholar
  8. 8.
    Siemiatycki J. Risk Factors for Cancer in the Workplace. Boca Raton, FL (USA): CRC Press, 1991.Google Scholar
  9. 9.
    Kiesselbach N, Korallus U, Lange HJ, Neiss HJ, Zwingers T. Bericht uber eine prospektive epidemiologische studie mit zuruck verlegtem eginn bei mitarbeitern des Leverkusener Werkes der Bayer AG mit acrylnitril (ACN) exposition [A report on a prospective epidemiologic study of workers at the Leverkusen plant of Bayer AG with acrylonitrile (ACN) exposure]. Zentralbl Arbeitsmed Abeitsschutz Prophyl Ergon 1979; 29: 256–9.Google Scholar
  10. 10.
    Thiess AM, Frentzel-Beyme R, Link R, Wild H. Mortali-tatsstudie bei chemiefacharbeitern verschiedener produktionsbetriebe mit exposition auch gegenuber acryl-nitril [Mortality study in chemical personnel of various industries exposed to acrylonitrile]. Zentralbl Arbeitsmed Arbeitsschutz Prophyl Ergon 1980; 30: 259–67.Google Scholar
  11. 11.
    Werner JB, Carter JT. Mortality of United Kingdom acry-lonitrile polymerisation workers. Br J Ind Med 1981; 38: 247–53.Google Scholar
  12. 12.
    Delzell E, Monson RR. Mortality among rubber workers exposed to acrylonitrile. J Occup Med 1982; 24: 767–9.Google Scholar
  13. 13.
    O'Berg MT, Chen JL, Burke CA, Walrath J, Pell S. Epidemiologic study of workers exposed to acrylonitrile: an update. J Occup Med 1985; 27: 835–40.Google Scholar
  14. 14.
    Chen JL, Walrath J, O'Berg MT, Burke CA, Pell S. Cancer incidence and mortality among workers exposed to acry-lonitrile. Am J Ind Med 1987; 11: 157–63.Google Scholar
  15. 15.
    Collins JJ, Page LC, Caporossi JC, Utidjian HM, Lucas LJ. Mortality patterns among employees exposed to acry-lonitrile. J Occup Med 1989; 31: 368–71.Google Scholar
  16. 16.
    Swaen GMH, Bloemen LJN, Twisk J, Scheffers T, Slangen JJM, Sturmans F. Mortality of workers exposed to acrylo-nitrile. J Occup Med 1992; 34: 801–5.Google Scholar
  17. 17.
    Mastrangelo G, Serena R, Marzia V. Mortality from tumours in workers in an acrylic fibre factory. Occup Med1993; 43: 155–8.Google Scholar
  18. 18.
    Sakurai I, Onodera M, Utsunomiya T, Minakuchi H, Iwai H, Matsumura H. Health effects of acrylonitrile in acrylic fibre factories. Br J Ind Med 1978; 35: 219–22.Google Scholar
  19. 19.
    Houthuijs D, Remijn B, Willems H, Boieij J, Biersteker K. Biologic monitoring of acrylonitrile exposure. Am J Ind Med 1982; 3: 313–20.Google Scholar
  20. 20.
    Jakubowski M, Linhart I, Pielas G, Kopecky J. 2-Cyano-ethylmercapturic acid (CEMA) in the urine as possible indicator of exposure to acrylonitrile. Br J Ind Med 1987; 44: 834–40.Google Scholar
  21. 21.
    Stewart P, Lemanski D, White D, et al. Exposure assessment for a study of workers exposed to acrylonitrile. I. Job exposure profiles: A computerized data management system for occupational epidemiologic studies. Appl Occup Environ Hyg 1992; 7: 820–5.Google Scholar
  22. 22.
    Stewart PA, Triolo H, Zey J, et al. Exposure assessment for a study of workers exposed to acrylonitrile. II. A computerized exposure assessment program. Appl Occup Environ Hyg 1995; 10: 698–706.Google Scholar
  23. 23.
    International Agency for Research on Cancer. Some Aromatic Amines, Hydrazine and Related Substances, N-nitroso Compounds and Miscellaneous Alkylating Agents.Lyon, France: IARC, 1974; IARC Monogr Eval Carcinog Risks Humans, Vol. 4: 231–45.Google Scholar
  24. 24.
    Travenius SZ. Formation and occurrence of Bis(chlo-romethyl) ether and its prevention in the chemical industry. Scand J Work Environ Health 1982; 8(Suppl 3): 1–36.Google Scholar
  25. 25.
    Laskin S, Drew RT, Cappiello V, Kuschner M, Nelson N. Inhalation carcinogenicity of alpha halo ethers. II. Chronic inhalation studies with chloromethyl methyl ether. Arch Environ Health 1975; 30: 70–2.Google Scholar
  26. 26.
    Thiess AM, Hey W, Zeller H. Zur toxikologie von dichlordimethylather - verdacht auf kanxerogene workung auch beim menschen. Zentralbl Arbeitsmed 1973; 23: 97–102.Google Scholar
  27. 27.
    Collingwood KW, Pasternack BS, Shore RE. An industry-wide study of respiratory cancer in chemical workers exposed to chloromethyl ethers. JNCI 1987; 78: 1127–36.Google Scholar
  28. 28.
    Maher KV, Defonso LR. Respiratory cancer among chlo-romethyl ether workers. JNCI 1987; 78: 839–43.Google Scholar
  29. 29.
    Gowers DS, DeFonso LR, Schaffer P, et al. Incidence of respiratory cancer among workers exposed to chloromethylethers. Am J Epidemiol 1993; 137: 31–42.Google Scholar
  30. 30.
    Weiss W. Epidemic curve of respiratory cancer due to chlo-romethyl ethers. JNCI 1982; 69: 1265–9.Google Scholar
  31. 31.
    International Agency for Research on Cancer. Occupational Exposures to Mists and Vapours from Strong Inorganic Acids; and Other Industrial Chemicals. Lyon, France: IARC, 1974; IARC Monogr Eval Carcinog Risks Humans, Vol. 54: 237–85.Google Scholar
  32. 32.
    Birnbaum LS. A brief survey of butadiene health effects: a role for metabolic differences. Environ Health Perspect1993; 101 (Suppl 6): 161–7.Google Scholar
  33. 33.
    McMichael AJ, Spirtas R, Gamble JF, Tousey PM. Mortality among rubber workers: relationship to specific jobs. J Occup Med 1976; 18: 178–85.Google Scholar
  34. 34.
    Meinhardt TJ, Lemen RA, Crandall MS, Young RJ. Environmental epidemiology investigation of the styrene-butadiene rubber industry. Scand J Work Environ Health1982; 8: 250–9.Google Scholar
  35. 35.
    Matanoski GM, Santos-Burgoa C, Schwartz L. Mortality of a cohort of workers in the styrene-butadiene polymer manufacturing industry (1943–1982). Environ Health Perspect1990; 86: 107-17.Google Scholar
  36. 36.
    Divine BJ. An update on mortality among workers at a 1,3-butadiene facility. Preliminary results. Environ Health Perspect 1990; 86: 119–28.Google Scholar
  37. 37.
    Santos-Burgoa C, Matanoski GM, Zeger S, Schwartz L. Lymphohematopoietic cancer in styrene-butadiene polym-erization workers. Am J Epidemiol 1992; 136: 843–54.Google Scholar
  38. 38.
    Cowles SR, Tsai SP, Snyder PJ, Ross CE. Mortality, morbidity, and haematological results from a cohort of long term workers involved in 1,3-butadiene monomer production. Occup Environ Med 1994; 51: 323–9.Google Scholar
  39. 39.
    Cole P, Delzell E, Acquavella J. Exposure to butadiene and lymphatic and hematopoietic cancer. Epidemiology 1993; 4: 96–103.Google Scholar
  40. 40.
    International Agency for Research on Cancer. Some Industrial Chemicals. Lyon, France: IARC, 1994; IARC Monogr Eval Carcinog Risks Humans, Vol.60: 73–159.Google Scholar
  41. 41.
    Tardiff R, Goyal R, Brodeur J, Gerin M. Species differences in the urinary disposition of some metabolites of ethylene oxide. Fundam Appl Toxicol 1987; 9: 448–53.Google Scholar
  42. 42.
    Hogstedt C, Malmqvist N, Wadman B. Leukemia in workers exposed to ethylene oxide. JAMA 1979; 241: 1132–3.Google Scholar
  43. 43.
    Hogstedt C, Rohlen O, Berndtsson BS, Axelson O, Ehren-berg L. A cohort study of mortality and cancer incidence in ethylene oxide production workers. Br J Ind Med 1979; 36: 276–80.Google Scholar
  44. 44.
    Hogstedt C, Aringer L, Gustavsson A. Epidemiologic support for ethylene oxide as a cancer-causing agent. JAMA1986; 255: 1575–8.Google Scholar
  45. 45.
    Hogstedt C. Epidemiological studies on ethylene oxide and cancer: an updating. In: Bartsch H, Hemminki K, O'Neill IK, eds. Methods for Detecting DNA Damaging Agents in Human Applications in Cancer Epidemiology and Prevention. Lyon, France: IARC, 1988; IARC Sci Pub. No. 89: 265–70.Google Scholar
  46. 46.
    Gardner MJ, Coggon D, Pannett B, Harris EC. Workers exposed to ethylene oxide: a follow up study. Br J Ind Med1989; 46: 860–5.Google Scholar
  47. 47.
    Benson LO, Teta MJ. Mortality due to pancreatic and lymphopoietic cancers in chlorohydrin production workers. Br J Ind Med 1993; 50: 710–6.Google Scholar
  48. 48.
    Kiesselbach N, Ulm K, Lange HJ, Korallus U. A multicen-tre mortality study of workers exposed to ethylene oxide. Br J Ind Med 1990; 47: 182–8.Google Scholar
  49. 49.
    Hagmar L, Welinder H, Linden K, Attewell R, Osterman-Golkar S, Tornqvist M. An epidemiological study of cancer risk among workers exposed to ethylene oxide using hemoglobin adducts to validate environmental exposure assessments. Int Arch Occup Environ Health 1991; 63: 271–7.Google Scholar
  50. 50.
    Steenland K, Stayner L, Greife A, et al. Mortality among workers exposed to ethylene oxide. New Engl J Med 1991; 324: 1402–7.Google Scholar
  51. 51.
    Stayner L, Steenland K, Greife A, et al. Exposure-response analysis of cancer mortality in a cohort of workers exposed to ethylene oxide. Am J Epidemiol 1993; 138: 787–98.Google Scholar
  52. 52.
    Teta MJ, Benson LO, Vitale JN. Mortality study of ethylene oxide workers in chemical manufacturing: a 10 year update. Br J Ind Med 1993; 50; 704–9.Google Scholar
  53. 53.
    Bisanti L, Maggini M, Raschetti R, et al. Cancer mortality in ethylene oxide workers. Br J Ind Med 1993; 50: 317–24.Google Scholar
  54. 54.
    Norman SA, Berlin JA, Soper KA, Middendorf BF, Stolley PD. Cancer incidence in a group of workers potentially exposed to ethylene oxide. Int J Epidemiol 1995; 24: 276–84.Google Scholar
  55. 55.
    Shore RE, Gardner MJ, Pannett B. Ethylene oxide: an assessment of the epidemiological evidence on carcino-genicity. Br J Ind Med 1993; 50: 971–97.Google Scholar
  56. 56.
    International Agency for Research on Cancer. Wood Dust and Formaldehyde. Lyon, France: IARC, 1995; IARC Monogr Eval Carcinog Risks Humans, Vol. 55: 217–362.Google Scholar
  57. 57.
    Kerns WD, Donofrio DJ, Gralla EJ, Swenberg JA. Car-cinogenicity of formaldehyde in rats and mice after long-term inhalation exposure. Cancer Res 1983; 43: 4382–92.Google Scholar
  58. 58.
    Woutersen RA, van Garderen-Hoetmer A, Bruijntjes JP, Zwart A, Feron VJ. Nasal tumours in rats after severe injury to the nasal mucosa and prolonged exposure to 10 ppm formaldehyde. J Appl Toxicol 1989; 9: 39–46.Google Scholar
  59. 59.
    Monticello TM, Morgan KT, Everitt JI, Popp JA. Effects of formaldehyde gas on the respiratory tract of rhesus monkeys. Pathology and cell proliferation. Am J Pathol1989; 134: 515–27.Google Scholar
  60. 60.
    Monticello TM, Gross EA, Morgan KT. Cell proliferation and nasal carcinogenesis. Environ Health Perspect 1993; 101 (Suppl 5): 121–4.Google Scholar
  61. 61.
    Blair A, Stewart PA, O'Berg M, et al. Mortality among industrial workers exposed to formaldehyde. JNCI 1986; 78: 1071–84.Google Scholar
  62. 62.
    Blair A, Stewart PA, Hoover RN, et al. Cancers of the nasopharynx and oropharynx and formaldehyde exposure. JNCI 1987; 78: 191–2.Google Scholar
  63. 63.
    Blair A, Stewart PA, Hoover RN. Mortality from lung cancer among workers employed in formaldehyde industries. Am J Ind Med 1990; 17: 683–99.Google Scholar
  64. 64.
    Stewart PA, Blair A, Cubit DA, et al. Estimating historical exposures to formaldehyde in a retrospective mortality study. Appl Ind Hyg 1986; 1: 34–41.Google Scholar
  65. 65.
    Gardner MJ, Pannett B, Winter PD, Cruddas AM. Acohort study of workers exposed to formaldehyde in the British chemical industry: an update. Br J Ind Med1993; 50: 827–34.Google Scholar
  66. 66.
    Bertazzi PA, Pesatori AC, Guercilena S, Consonni D, Zocchetti C. Cancer risk among workers producing for-maldehyde-based resins: extension of follow-up. Med Lav1989; 80: 111–22.Google Scholar
  67. 67.
    Stayner LT, Elliott L, Blade L, Keenlyside R, Halperin W. A retrospective cohort mortality study of workers exposed to formaldehyde in the garment industry. Am J Ind Med1988; 13: 667–81.Google Scholar
  68. 68.
    Andjelkovich DA, Janszen DB, Brown MH, Richardson RB, Miller FJ. Mortality of iron foundry workers. IV. Analysis of a subcohort exposed to formaldehyde. J Occup Med 1995; 37: 826–37.Google Scholar
  69. 69.
    Hall A, Harrington JM, Aw TC. Mortality study of British pathologists. Am J Ind Med 1991; 20: 83–9.Google Scholar
  70. 70.
    Walrath J, Fraumeni JF Jr. Mortality patterns among embalmers. Int J Cancer 1983; 31: 407–11.Google Scholar
  71. 71.
    Walrath J, Fraumeni JF Jr. Cancer and other causes of death among embalmers. Cancer Res 1984; 44: 4638–41.Google Scholar
  72. 72.
    Levine RJ, Andjelkovich DA, Shaw LK. The mortality of Ontario undertakers and a review of formaldehyde-related mortality studies. J Occup Med 1984; 26: 740–6.Google Scholar
  73. 73.
    Stroup NE, Blair A, Erikson GE. Brain cancer and other causes of death in anatomists. JNCI 1986; 77: 1217–24.Google Scholar
  74. 74.
    Hayes RB, Blair A, Stewart PA, Herrick RF, Mahar H.Mortality of US embalmers and funeral directors. Am J Ind Med 1990; 18: 641–52.Google Scholar
  75. 75.
    Brinton LA, Blot WJ, Becker JA, et al. A case-control study of cancers of the nasal cavity and paranasal sinuses. Am J Epidemiol 1984; 119: 896–906.Google Scholar
  76. 76.
    Olsen JH, Jensen SP, Hink M, Faurbo K, Breum NO, Jensen OM. Occupational formaldehyde exposure and increased nasal cancer risk in man. Int J Cancer 1984; 34: 639–44.Google Scholar
  77. 77.
    Hayes RB, Raatgever JW, De Bruyn A, Gerin M. Cancer of the nasal cavity and paranasal sinuses, and formaldehyde exposure. Int J Cancer 1986; 37: 487–92.Google Scholar
  78. 78.
    Vaughan TL, Strader C, Davis S, Daling JR. Formaldehyde and cancers of the pharynx, sinus and nasal cavity: I. Oc-cupational exposures. Int J Cancer 1986; 38: 677–83.Google Scholar
  79. 79.
    Vaughan TL, Strader C, Davis S, Daling JR. Formaldehyde and cancers of the pharynx, sinus and nasal cavity: II. Residential exposures. Int J Cancer 1986; 38: 685–8.Google Scholar
  80. 80.
    Roush GC, Walrath J, Stayner LT, Kaplan SA, Flannery JT, Blair A. Nasopharyngeal cancer, sinonasal cancer, and occupations related to formaldehyde: a case-control study. JNCI 1987; 79: 1221–4.Google Scholar
  81. 81.
    Luce D, Gerin M, Leclerc A, Morcet JF, Brugere J, Gold-berg M. Sinonasal cancer and occupational exposure to formaldehyde and other substances. Int J Cancer 1993; 53: 224–31.Google Scholar
  82. 82.
    West S, Hildesheim A, Dosemeci M. Non-viral risk factors for nasopharyngeal carcinoma in the Philippines: results from a case-control study. Int J Cancer 1993; 55: 722–7.Google Scholar
  83. 83.
    Partanen T, Kauppinen T, Nurminen M, et al. Formalde-hyde exposure and respiratory and related cancers: a case-referent study among Finnish woodworkers. Scand J Work Environ Health 1985; 11: 409–15.Google Scholar
  84. 84.
    Hansen J, Olsen JH. Formaldehyde and cancer morbidity among male employees in Denmark. Cancer Causes Control 1995; 6: 354–60.Google Scholar
  85. 85.
    Ballarin C, Sarto F, Giacomelli L, Bartolucci CB, Clonfero E. Micronucleated cells in nasal mucosa of formaldehyde-exposed workers. Mutat Res 1992; 280: 1–7.Google Scholar
  86. 86.
    Suruda A, Schulte P, Boeniger M, et al. Cytogenetic effects of formaldehyde exposure in students of mortuary science. Cancer Epidemiol Biomark Prev 1993; 2: 453–60.Google Scholar
  87. 87.
    Blair A, Saracci R, Stewart PA, Hayes RB, Shy C. Epidem-iologic evidence on the relationship between formaldehyde exposure and cancer. Scand J Work Environ Health 1990; 16: 381–93.Google Scholar
  88. 88.
    McLaughlin JK. Formaldehyde and cancer: a critical review. Int Arch Occup Environ Health 1994; 66: 295–301.Google Scholar
  89. 89.
    Partanen T. Formaldehyde exposure and respiratory cancer - meta-analysis of the epidemiology evidence. Scand J Work Environ Health 1993; 19: 8–15.Google Scholar
  90. 90.
    International Agency for Research on Cancer. Some Aziri-denes, N-, S-, and O-mustards and Selenium. Lyon, France: IARC, 1975; IARC Monogr Eval Carcinog Risks Humans,Vol. 9: 181–92.Google Scholar
  91. 91.
    Boursnell JC, Cohen JA, Dixon M, et al. Studies on mustard gas (Dichlorodiethylsulphide) and some related com-pounds. V. The fate of injected mustard gas (containing radioactive sulphur) in the animal body. Biochem J 1946; 40: 756–64.Google Scholar
  92. 92.
    Case RA, Lea AJ. Mustard-gas poisoning, chronic bron-chitis and lung cancer: investigation into possibility that poisoning by mustard gas in 1914–18 war might be factor in production of neoplasia. Br J Prev Soc Med 1955; 9: 62-72.Google Scholar
  93. 93.
    Beebe GW. Lung cancer in World War I veterans: Possible relation to mustard-gas injury and 1918 influenza epidemic. JNCI 1960; 25: 1231–51.Google Scholar
  94. 94.
    Norman JE Jr. Lung cancer mortality in World War I veterans with mustard-gas injury: 1919–1965. JNCI 1975; 54: 311-7.Google Scholar
  95. 95.
    Nishimoto Y, Yamakido M, Ishioka S, Shigenobu T, Yuku-take M. Epidemiologic studies of lung cancer in Japanese mustard gas workers. In: Miller RW, ed. Unusual Occurrences as Clues to Cancer Etiology. Tokyo, Japan: Taylor and Francis, LTD, 1988: 95–101.Google Scholar
  96. 96.
    Easton DF, Peto J, Doll R. Cancers of the respiratory tract in mustard gas workers. Br J Ind Med 1988; 45: 652–9.Google Scholar
  97. 97.
    Takeshima Y, Inai K, Bennett WP, et al. P53 mutations in lung cancer from Japanese mustard gas workers. Carcino-genesis1994; 15: 2075–9.Google Scholar
  98. 98.
    International Agency for Research on Cancer. Occupational Exposures to Mists and Vapors from Strong Inorganic Acids; and Other Industrial Chemicals. Lyon, France: IARC, 1992; IARC Monogr Eval Carcinog Risks Humans, Vol. 54: 41–130.Google Scholar
  99. 99.
    US Environmental Protection Agency. Acid Rain. An EPA Journal Supplement. Washington DC: Office of Public Affairs, 1986.Google Scholar
  100. 100.
    Ichinose T, Sagai M. Combined exposure to NO2, O3, H2SO4-aerosol and lung tumor formation in rats. Toxicology1992; 74: 173–84.Google Scholar
  101. 101.
    Alderson MR, Rattan NS. Mortality of workers on an isopropyl alcohol plant and two MEK dewaxing plants. Br J Ind Med 1980; 37: 85–9.Google Scholar
  102. 102.
    Enterline PE. Importance of sequential exposure in the production of epichlorohydrin and isopropanol. Ann NY Acad Sci 1982; 381: 344–9.Google Scholar
  103. 103.
    Lynch J, Hanis NM, Bird MG, Murray KJ, Walsh JP. An association of upper respiratory cancer with exposure to diethyl sulfate. J Occup Med 1979; 21: 333–41.Google Scholar
  104. 104.
    Teta MJ, Perlman GD, Ott MG. Mortality study of ethanol and isopropanol production workers at two facilities. Scand J Work Environ Health 1992; 18: 90–6.Google Scholar
  105. 105.
    Beaumont JJ, Leveton J, Knox K, et al. Lung cancer mortality in workers exposed to sulfuric acid mist and other acid mists. JNCI 1987; 79: 911–21.Google Scholar
  106. 106.
    Steenland K. Laryngeal cancer incidence among workers exposed to acid mists (United States). Cancer Causes Control1997; 8: 34–38.Google Scholar
  107. 107.
    Steenland K, Beaumont J. Further follow-up and adjustment for smoking in a study of lung cancer and acid mists. Am J Ind Med 1989; 16: 347–54.Google Scholar
  108. 108.
    Blair A. Mortality among workers in the metal polishing and plating industry, 1951–1969. J Occup Med 1980; 22: 158-62.Google Scholar
  109. 109.
    Blair A, Mason TJ. Cancer mortality inUnitedStates counties with metal electroplating industries. Arch Environ Health1980; 35: 92–4.Google Scholar
  110. 110.
    Englander V, Sjoberg A, Hagmar L, et al. Mortality and cancer morbidity in workers exposed to sulfur dioxide in a sulphuric acid plant. Int Arch Occup Environ Health1988; 61: 157–62.Google Scholar
  111. 111.
    Forastiere F, Valesini S, Salimei E, Magliola E, Perucci CA. Respiratory cancer among soap production workers. Scand J Work Environ Health 1987; 13: 258–60. Google Scholar
  112. 112.
    Cooper WC, Wong O, Kheifets L. Mortality among employees of lead battery plants and lead-producing plants, 1947–1980. Scand J Work Environ Health 1985; 11: 331-45.Google Scholar
  113. 113.
    Soskolne CL, Zeighami EA, Hanis NM, et al. Laryngeal cancer and occupational exposure to sulfuric acid. Am J Epidemiol 1984; 120: 358–69.Google Scholar
  114. 114.
    Zemla B, Day N, Swiatnicka J, Banasik R. Larynx cancer risk factors. Neoplasma 1987; 34: 223–33.Google Scholar
  115. 115.
    Brown LM, Mason TJ, Pickle LW, Stewart PA, et al. Occupational risk factors for laryngeal cancer on the Texas Gulf coast. Cancer Res 1988; 48: 1960–4.Google Scholar
  116. 116.
    Soskolne CI, Jhangri GS, Siemiatycki J, et al. Occupational exposure to sulfuric acid associated with laryngeal cancer. Scand J Work Environ Health 1992; 18: 225–32.Google Scholar
  117. 117.
    Yamaguchi N, Kido M, Hoshuyama T, et al. A case-control study of occupational lung cancer risks in an industrialized city of Japan. Jpn J Cancer Res1992; 83: 134–40.Google Scholar
  118. 118.
    Leikauf GD, Spektor DM, Albert RE, Lippmann M. Dose-dependent effects of submicrometer sulfuric acids aerosol on particle clearance from ciliated human lung airways. Am Ind Hyg Assoc J 1984; 45: 285–92.Google Scholar
  119. 119.
    International Agency for Research on Cancer. Some Monomers, Plastics and Synthetic Elastomers, and Acrolein. Lyon, France: IARC, 1979; IARC Monogr Eval Carcinog Risks Humans. Vol. 19: 377–438.Google Scholar
  120. 120.
    Radike MJ, Stemmer KI, Bingham E. Effect of ethanol on vinyl chloride carcinogenesis. Environ Health Perspect 1981; 41: 59–62.Google Scholar
  121. 121.
    Creech JL Jr, Johnson MN. Angiosarcoma of liver in the manufacture of polyvinyl chloride. J Occup Med 1974; 16: 150–1.Google Scholar
  122. 122.
    Jones RD, Smith DM, Thomas PG. A mortality study of vinyl chloride monomer workers employed in the United Kingdom in 1940–1974. Scand J Work Environ Health 1988; 14: 153-60.Google Scholar
  123. 123.
    Smulevich VB, Fedotova IV, Filatova VS. Increasing evidence of the rise of cancer in workers exposed to vinyl-chloride. Br J Ind Med 1988; 45: 93–7.Google Scholar
  124. 124.
    Wu W, Steenland K, Brown D, et al. Cohort and case-control analyses of workers exposed to vinyl chloride: an update. J Occup Med 1989; 31: 518–23.Google Scholar
  125. 125.
    Hagmar L, Akesson B, Nielsen J, et al. Mortality and cancer morbidity in workers exposed to low levels of vinyl chloride monomer at a polyvinyl chloride processing plant. Am J Ind Med 1990; 17: 553–65.Google Scholar
  126. 126.
    Simonato L, L'Abbe KA, Andersen A, et al. Acollaborative study of cancer incidence and mortality among vinyl chloride workers. Scand J Work Environ Health 1991; 17: 159–69.Google Scholar
  127. 127.
    Laplanche A, Calvel-Chapelon F, Contassot JC, Lanouz-iere C. Exposure to vinyl chloride monomer: results of a cohort study after a seven year follow up. Br J Ind Med1992; 49: 134–7.Google Scholar
  128. 128.
    Dell L, Teta MJ. Mortality among workers at a plastics manufacturing and research and development facility: 1946–1988. Am J Ind Med 1995; 28: 373-84.Google Scholar
  129. 129.
    Trivers GE, Cawley HL, DeBenedetti VMG, et al. Anti-p53 antibodies in sera of workers occupationally exposed to vinyl chloride. JNCI 1995; 87: 1400–7.Google Scholar

Copyright information

© Chapman and Hall 1997

Authors and Affiliations

  • Aaron Blair
    • 1
  • Neely Kazerouni
    • 1
  1. 1.Occupational Studies SectionNational Cancer InstituteRockvilleUSA

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