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Epoxidation of alkanes and cycloalkanes by microbial lipases immobilized with photo-crosslinkable resin prepolymer

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Abstract

Using commercial lipases immobilized in gels prepared from photo-crosslinkable prepolymers, n-alkenes (C 6 -C 12) and cyclic alkenes (C 5 -C 12 ) were converted to corresponding epoxides. Cyclooctene was converted most effectively with 54.5% of the maximum conversion by Candida cylindracea lipase immobilized in hydrophobic gel prepared from a photo-crosslinkable prepolymer, ENTP-4000. Substrates substituted with hydrophobic groups were epoxided, but the ones with hydrophilic groups were not epoxided.

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Authors and Affiliations

  1. Laboratory of Molecular Biotechnology, Department of Applied Biological Science, School of Agricultural Science, Nagoya University, 1 Furo-cho, Chikusa-ku Nagoya, Japan

    Yuki Miura

  2. Technical Research Laboratory, Kansai Paint, 4-17-1 Higashi-Yawata, Hiratsuka Kanagawa, Japan

    Tsuneo Yamane

Authors
  1. Yuki Miura
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  2. Tsuneo Yamane
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Miura, Y., Yamane, T. Epoxidation of alkanes and cycloalkanes by microbial lipases immobilized with photo-crosslinkable resin prepolymer. Biotechnology Letters 19, 611–613 (1997). https://doi.org/10.1023/A:1018370227482

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  • DOI: https://doi.org/10.1023/A:1018370227482

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