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Antiprogestagen Activity of 5H-Progesterone Metabolites and Their Analogues, 16α,17α-Cyclohexane-5H-Pregnan-3,20-Diones

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Abstract

Antiprogestin activity of 5H-progesterone metabolites and their analogues 16α,17α-cyclohexan-5H-pregnan-3,20-diones was tested on rats. Modified pregnancy interruption test showed that 5α (H)-isomers of natural and synthetic hormones exhibit maximum activity.

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Authors and Affiliations

  1. Department of Molecular Pharmacology and Radiobiology, Medical Biological Faculty of the Russian State Medical University, Russia

    E. N. Kareva, A. V. Kamernitskii, I. S. Levina, N. V. Kirpichnikova, L. E. Kulikova & V. V. Podval'nyuk

  2. Group of Steroid and Oxylipin Chemistry, N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Science, Moscow

    E. N. Kareva, A. V. Kamernitskii, I. S. Levina, N. V. Kirpichnikova, L. E. Kulikova & V. V. Podval'nyuk

Authors
  1. E. N. Kareva
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  2. A. V. Kamernitskii
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  3. I. S. Levina
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  4. N. V. Kirpichnikova
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  5. L. E. Kulikova
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  6. V. V. Podval'nyuk
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Kareva, E.N., Kamernitskii, A.V., Levina, I.S. et al. Antiprogestagen Activity of 5H-Progesterone Metabolites and Their Analogues, 16α,17α-Cyclohexane-5H-Pregnan-3,20-Diones. Bulletin of Experimental Biology and Medicine 131, 340–341 (2001). https://doi.org/10.1023/A:1017995917908

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  • DOI: https://doi.org/10.1023/A:1017995917908

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