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Passive cigarette smoke and renal glyoxalase system

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Abstract

Cigarette smoking is associated with a number of fatal diseases, including cancer of different organs. A number of oxoaldehydes are found in cigarette smoke, among which methylglyoxal (MG) is known to cause toxicity to cells upon accumulation. In biological systems, MG is converted to s-d-lactoylglutathione by glyoxalase I with reduced glutathine (GSH) as a cofactor, and s-d-lactoylglutathione is converted to D-lactic acid with simultaneous regeneration of GSH, by glyoxalase II. In the present study, we have investigated the status of the glyoxalase enzymes in kidney tissues from rats exposed to passive cigarette smoke. No significant change has been noted in glyoxalase I activity. Glyoxalase II was decreased during 1 and 2 weeks of exposure, and after that the activity was increased. The initial decrease in the activity of gly II may be due to the excess amount of methylglyoxal generated due to smoke exposure or the adduct formed by MG and GSH which known to inhibit gly II activity. Both enzymes help in the detoxification of cigarette smoke induced chemicals and biochemicals.

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Authors and Affiliations

  1. Department of Biochemistry, Meharry Medical College, Nashville, TN, 37208, USA

    Swati Biswas & Salil K. Das

  2. Tobacco and Health Research Institute, University of Kentucky, Lexington, KY, 40536, USA

    C. Gary Gairola

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  1. Swati Biswas
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  2. C. Gary Gairola
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Biswas, S., Gairola, C.G. & Das, S.K. Passive cigarette smoke and renal glyoxalase system. Mol Cell Biochem 229, 153–156 (2002). https://doi.org/10.1023/A:1017992403656

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