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Effects of Cold Stress and Epinephrine on Degranulation of Peritoneal Mast Cells in Rats

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Abstract

We studied the effects of histamine liberators calcium ionophore A23187 and substance 48/80 on mast cells during cold stress and epinephrine load. Under the effect of both stress factors, ionophore A23187-induced histamine release from mast cells underwent more pronounced changes than that stimulated by substance 48/80. Cold stress and epinephrine load produce different changes in functional activity of Ca2+ channels in mast cell membranes.

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Authors and Affiliations

  1. Department of Biophysics, Laboratory of Radiational Biophysics, Biological Faculty, M. V. Lomonosov Moscow State University, Russia

    E. E. Graevskaya, M. Ya. Akhalaya & E. N. Goncharenko

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  1. E. E. Graevskaya
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  2. M. Ya. Akhalaya
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  3. E. N. Goncharenko
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Graevskaya, E.E., Akhalaya, M.Y. & Goncharenko, E.N. Effects of Cold Stress and Epinephrine on Degranulation of Peritoneal Mast Cells in Rats. Bulletin of Experimental Biology and Medicine 131, 333–335 (2001). https://doi.org/10.1023/A:1017991817000

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  • DOI: https://doi.org/10.1023/A:1017991817000

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