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Morphological Ground of Formation of the Brain Choroid Plexus Blood-Cerebrospinal Fluid Barrier in Human Prenatal Ontogenesis

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Abstract

Using light and electron microscopy and immunocytochemistry methods, structural organization of the formed blood-cerebrospinal fluid barrier (BCSFB) of the human brain choroid plexus in embryos of 6–9 weeks of development was studied. The main structures peculiar to the mature BCSFB have been established to appear with formation of the choroid plexus at the end of the 2nd month of the human intrauterine development. Fenestrae in the choroid plexus capillary endothelium are revealed since the 9th week of prenatal development. Characteristic of the human embryonic BCSFB are a poor development of the plexus capillary basal membrane, scanty pericytes, a high activity of interstitial macrophages, which suggests the barrier immaturity. A significant amount of cytoplasmic glycogen inclusions revealed in plexus epitheliocytes seems to be due to peculiar trophic requirements of developing brain cells under conditions of an insufficient development of the local blood supply.

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REFERENCES

  1. Kassil', G.N., Gemato-entsefalicheskii bar'er (Blood—Brain Barrier), Moscow, 1963.

  2. Rosin, Ya.A., History and Theory of the Blood-Brain Barrier and Its Terminology, Fiziologiya gisto-gematicheskih bar'erov. Ser. “Rukovodstvo po fiziologii” (Physiology of Tissue-Blood Barriers. Series “Handbook of Physiology”), Moscow, 1977, pp. 119–126.

  3. Przijalkowsky, W., Lipowski, D., Kolasa, T., et al., Bariera Krewplyn Mozgowo-Rdzeniowy y Ropnyh Zapaleniach Opon Mozgowo-Rdzeniowych i Mozgu, Neurol. Neurochir. Pol., 1996, vol. 30, pp. 39–48.

    Google Scholar 

  4. Tuomanen, E., Entry of Pathogen into the Central Nervous System, FEMS Microbiol. Rev., 1996, vol. 18, pp. 289–299.

    Google Scholar 

  5. Saunders, N.R., Habood, M.D., and Dziegielewska, K.M., Barrier Mechanisms in the Brain. I. Adult Brain, Clin. Exp. Pharmacol. Physiol., 1999, vol. 26, pp. 11–19.

    Google Scholar 

  6. Hampel, H., Kotter, H.U., and Moller, H.J., Blood-Cerebrospinal Fluid Barrier Dysfunction for High Molecular Weight Proteins in Alzheimer Disease and Major Depression: Indication for Disease Subsets, Alzheimer Disease Assoc. Disord., 1997, vol. 11, pp. 78–87.

    Google Scholar 

  7. Liebsch, R., Kornhuber, M.E., Dietl, D., et al., Blood-CSF Barrier Integrity in Multiple Sclerosis, Acta Neurol. Scand.,1996, vol. 94, pp. 404–410.

    Google Scholar 

  8. Qin, D., Ma, J., Xiao, J., and Tang, Z., Effect of Brain Irradiation on Blood-CSF Barrier Permeability of Chemotherapeutic Agents, Am. J. Clin. Oncol., 1997, vol. 20, pp. 263–265.

    Google Scholar 

  9. Bayard-Burfiels, L., Alling, C., Blennow, K., et al., Impairment of the Blood CSF Barrier in Suicide Attempters, Eur. Neuropsychopharmacol., 1996, vol. 6, pp. 195–199.

    Google Scholar 

  10. Sturrock, R.R., A Morphological Study of the Development of the Mouse Choroid Plexus, J. Anat., 1979, vol. 129, pp. 777–793.

    Google Scholar 

  11. Zaki, W., Ultrastructure of the Choroid Plexus and Its Development in the Mouse, Z. Mikrosk. Anat. Forsch., 1981, vol. 27, no. 6, pp. 1424–1429.

    Google Scholar 

  12. O'Rahilly, R., Bossy, J., and Muller, F., Introduction a l'Etude des Stades Embryonnaires chez l'Homme, Bull. Assoc. Anat., 1981, vol. 65, no. 189, pp. 141–236.

    Google Scholar 

  13. Dohrmann, G.J. and Bucy, P.C., Human Choroid Plexus: A Light and Electron Microscopic Study, J. Nurosurg., 1970, vol. 33, pp. 506–516.

    Google Scholar 

  14. O'Rahilly, R. and Muller, F., The Meninges in Human Development, J. Neuropathol. Exp. Neurol., 1986, vol. 45, pp. 588–608.

    Google Scholar 

  15. Osaka, K., Handa, H., Matsumoto, S., and Yasuda, M., Development of the Cerebrospinal Fluid Pathway in the Normal and Abnormal Human Embryos, Childs Brain, 1980, vol. 6, pp. 26–38.

    Google Scholar 

  16. Keep, R.F. and Jones, H.C., A Morphometric Study of the Development of the Lateral Ventricle Choroid Plexus, Choroid Plexus Capillaries and Ventricular Ependyma in the Rat, Dev. Brain Res., 1990, vol. 56, pp. 47–53.

    Google Scholar 

  17. Bauer, H.C., Bauer, H., and Lametschwandtner, A., Neovascularization and the Appearance of Morphological Characteristics of the Blood-Brain Barrier in the Embryonic Mouse Central Nervous System, Dev. Brain Res., 1993, vol. 75, pp. 269–278.

    Google Scholar 

  18. Yoshida, Y., Yamada, M., Wakabayashi, K., and Ikuta, F., Endothelial Fenestrae in the Rat Fetal Cerebrum, Dev. Brain Res., 1988, vol. 44, pp. 211–219.

    Google Scholar 

  19. Korzhevskii, D.E., Omel'chenko, N.V., Smirnov, E.B., and Petrova, E.S., Structure of Formed Blood Vessel of the Anlage of the Human Embryonic Neocortex, Morfologiya, 2000, vol. 117, no. 2, pp. 51–56.

    Google Scholar 

  20. Jucker, M., Tian, M., and Ingram, D.K., Laminins in the Adult and Aged Brain, Mol. Chem. Neuropathol., 1996, vol. 28, pp. 209–218.

    Google Scholar 

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  1. Russian Academy of Medical Sciences, Institute of Experimental Medicine, St. Petersburg, Russia

    D. E. Korzhevskii & V. A. Otellin

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  1. D. E. Korzhevskii
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  2. V. A. Otellin
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Korzhevskii, D.E., Otellin, V.A. Morphological Ground of Formation of the Brain Choroid Plexus Blood-Cerebrospinal Fluid Barrier in Human Prenatal Ontogenesis. Journal of Evolutionary Biochemistry and Physiology 37, 200–204 (2001). https://doi.org/10.1023/A:1017697200837

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