Abstract
The aminomethylation of (Z)-1-hydroxy-3-methylpent-2-en-4-yne with paraformaldehyde and secondary amines has been studied. The reaction was established to begin with the formation of vinylacetylenic monoadducts, which under the action of the aminomethylating agent are heterocyclized into the corresponding α-(1,3-bis-N,N-dialkylaminoprop-2-yl)-β-methylfurans.
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Mavrov, M.V., Simirskaya, N.I. Interaction of (Z)-1-Hydroxy-3-methylpent-2-en-4-yne with CH2O-Secondary Amine System. New Route to Form α-(1,3-Bis-N,N-dialkylaminoprop-2-yl)furans. Chemistry of Heterocyclic Compounds 37, 276–282 (2001). https://doi.org/10.1023/A:1017594613654
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DOI: https://doi.org/10.1023/A:1017594613654