Abstract
5-Benzylidenehydantoin reacts with chlorosulfonic acid to give the corresponding p-sulfonyl chloride. Condensation of the latter with amino acids leads to sulfonylamino acid derivatives, which on coupling with glycine methyl ester hydrochloride in THF-Et3N using the dicyclohexylcarbodiimide method furnish the desired dipeptide methyl esters. The spectral data of the compounds are briefly discussed.
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El-Sayed, R.A. Synthesis of Some Novel Benzylidenehydantoins: Amino Acids Derivatives. Chemistry of Heterocyclic Compounds 37, 91–94 (2001). https://doi.org/10.1023/A:1017592817982
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DOI: https://doi.org/10.1023/A:1017592817982