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Nucleophilic Substitution in 1,5-Benzodiazepin-2-ones

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The reaction of 3-bromo-4-phenyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one with cyclic amines gives 3-aminoalkyl-4-phenyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one. Thiazolo[4,5-b][1,5]benzodiazepine was isolated along with the substitution product when thiourea was used.

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Bozhanov, V.I., Ivonin, S.P. Nucleophilic Substitution in 1,5-Benzodiazepin-2-ones. Chemistry of Heterocyclic Compounds 36, 1446–1448 (2000). https://doi.org/10.1023/A:1017578614850

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  • DOI: https://doi.org/10.1023/A:1017578614850

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