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Investigations of Imidazoles. 101. Synthesis of 2,3-Dihydroimidazo[1,2-a]pyrimidine from 2-Aminopyrimidine

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Two novel preparative methods have been developed for the synthesis of 2,3-dihydroimidazo[1,2-a]pyrimidine from 2-aminopyrimidine. These are the reaction with 1,2-dibromoethane and also the reaction with ethylene chloro(bromo)hydrin, subsequent treatment of 1-β-hydroxyethyl-2-imino-1,2-dihydropyrimidine with thionyl chloride, and cyclization of the intermediate 1-β-chloroethyl-2-imino-1,2-dihydropyrimidine in the presence of sodium hydroxide.

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REFERENCES

  1. P. M. Kochergin, I. A. Mazur, G. K. Rogul'chenko, E. V. Aleksandrova, and B. E. Mandrichenko, Khim. Geterotsikl. Soedin., 1674 (2000).

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Authors and Affiliations

  1. Center for the Chemistry of Medicinals. All Russian Chemical-Pharmaceutical Science Research Institute, 119815, Moscow

    P. M. Kochergin

  2. Zaporozhe State Medicinal University, 330074, Zaporozhe, Ukraine

    I. A. Mazur, G. K. Rogul'chenko, E. V. Aleksandrova & B. E. Mandrichenko

Authors
  1. P. M. Kochergin
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  2. I. A. Mazur
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  3. G. K. Rogul'chenko
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  4. E. V. Aleksandrova
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  5. B. E. Mandrichenko
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Kochergin, P.M., Mazur, I.A., Rogul'chenko, G.K. et al. Investigations of Imidazoles. 101. Synthesis of 2,3-Dihydroimidazo[1,2-a]pyrimidine from 2-Aminopyrimidine. Chemistry of Heterocyclic Compounds 37, 224–226 (2001). https://doi.org/10.1023/A:1017571617287

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  • DOI: https://doi.org/10.1023/A:1017571617287

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