Abstract
We elaborated a model of gastroduodenitis combined with hyperlipidemia in rats. This model is based on alimentary lipid disturbances and morphological changes in the gastroduodenal mucosa caused by exogenous damaging factors. Morphological assay revealed gastroduodenitis; biochemical studies of the blood and liver demonstrated hyperlipidemia. This model holds much promise for evaluating pathogenetic mechanisms of combined gastroduodenal and heart diseases.
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REFERENCES
V. G. Baranov, N. F. Baranov, and M. F. Belovintseva, Probl. Endokrinol., No. 6, 58-62 (1972).
A. I. Voloshin, Clinical and Experimental Substantiation of Successive Rehabilitation Therapy of Chronic Primary Gastroduodenitis, Abstract of Doct. Med. Sci. Dissertation, Chernovtsy (1988).
I. Goranov, K. Avramova, N. Donchev, et al., Vopr. Pitaniya, No. 4, 71-73 (1990).
V. V. Knyshova, Byull. Sib. Otd. Ros. Akad. Med. Nauk, No. 4, 80-84 (1998).
V. V. Korzhikov, Ulcer Diseases of the Stomach and Duodenum in Patients with Coronary Heart Disease, Abstract of Cand. Med. Sci. Dissertation, Moscow (1994).
A. A. Krylov, Ter. Arkh., No. 2, 121-124 (1992).
M. F. Nesterin, V. F. Markemova, B. G. Lyapkov, et al., Vopr. Pitaniya, No. 1, 32-36 (1979).
A. N. Perevertkina, Clinics, Diagnostics, and Therapy of Ulcer Diseases of the Stomach and Duodenum Combined with Coronary Heart Disease, Abstract of Cand. Med. Sci. Dissertation, Moscow (1990).
N. D. Polushina, Hormonal Mechanisms Underlying Primary Prevention of Gastroduodenal Ulcers by Drinking Mineral Water, Abstract of Doct. Med. Sci. Dissertation, Pyatigorsk (1993).
N. I. Tutchenko, Ya. V. Goer, L. S. Belyanskii, et al., Pat. Fiziol., No. 5, 54-55 (1990).
N. V. El'shtein, Rus. Med. Zh., No. 6, 344-352 (1997).
G. Bradgon, Lipids and the Steroid Hormones, Philadelphia (1960), p. 7.
B. Nery and C. Frings, Clin. Chem., 19, 1201-1202 (1973).
A. Robert, Ann. Clin. Res., No. 16, 335-338 (1984).
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Knyshova, V.V., Ivanova, I.L. & Kapitonova, V.G. A Model of Combined Gastroduodenitis and Hyperlipidemia in Rats. Bulletin of Experimental Biology and Medicine 131, 199–201 (2001). https://doi.org/10.1023/A:1017568617964
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DOI: https://doi.org/10.1023/A:1017568617964