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Potentiation of Antitumor Effects of Cisplatin by Tumor Necrosis Factor-β

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Abstract

Recombinant tumor necrosis factor-β potentiated the inhibitory effect of cisplatin on intramuscularly transplanted GA-1 tumor and liver metastasis in mice. The antitumor effect was related to cytotoxic and cytostatic activities of the test preparations rather than to initiation of apoptosis.

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Authors and Affiliations

  1. Research Construction-and-Technology Institute of Biologically Active Substances, Vektor State Research Center, Novosibirsk

    G. M. Sysoeva, V. A. Fadina, N. A. Popova, E. V. Nikitenko, V. P. Nikolin, S. I. Il'nitskaya & V. I. Kaledin

  2. Novosibirsk State University, Novosibirsk

    G. M. Sysoeva, V. A. Fadina, N. A. Popova, E. V. Nikitenko, V. P. Nikolin, S. I. Il'nitskaya & V. I. Kaledin

  3. Novosibirsk State Medical Academy, Novosibirsk

    G. M. Sysoeva, V. A. Fadina, N. A. Popova, E. V. Nikitenko, V. P. Nikolin, S. I. Il'nitskaya & V. I. Kaledin

  4. Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk

    G. M. Sysoeva, V. A. Fadina, N. A. Popova, E. V. Nikitenko, V. P. Nikolin, S. I. Il'nitskaya & V. I. Kaledin

Authors
  1. G. M. Sysoeva
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  2. V. A. Fadina
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  3. N. A. Popova
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  4. E. V. Nikitenko
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  5. V. P. Nikolin
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  6. S. I. Il'nitskaya
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  7. V. I. Kaledin
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Sysoeva, G.M., Fadina, V.A., Popova, N.A. et al. Potentiation of Antitumor Effects of Cisplatin by Tumor Necrosis Factor-β. Bulletin of Experimental Biology and Medicine 131, 159–161 (2001). https://doi.org/10.1023/A:1017548113421

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  • DOI: https://doi.org/10.1023/A:1017548113421

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