Skip to main content
SpringerLink
Log in

Antiphospholipid Syndrome: Ultrastructure of Microvascular Endotheliocytes in Musculocutaneous Bioptates during Systemic Lupus Erythematosus

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

    We’re sorry, something doesn't seem to be working properly.

    Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

Abstract

Degeneration and atrophy of the epidermis, disorganization of the connective tissue, focal atrophy of skeletal myocytes, and diffuse vasculopathy are the main pathomorphological signs found in musculocutaneous bioptates during the antiphospholipid syndrome associated with systemic lupus erythematosus. The major morphogenetic disorder is alteration of microvascular endotheliocytes accompanied by the formation of concentric perivascular mononuclear infiltrates.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. Z. S. Alekberova, T. M. Reshetnyak, S. G. Rodeska-Lopovok, et al., Ter. Arkh., No. 5, 41-44 (1995).

  2. Inflammation[in Russian], Eds. V. V. Serov and V. S. Paukov, Moscow (1995), pp. 558-569.

  3. A. A. Demin, L. M. Nepomnyashchikh, V. A. Galenok, and Z. S. Volkova, Histochemistry in Normal and Pathological Morphologies[in Russian], Novosibirsk (1967), pp. 161-165.

  4. V. P. Kaznacheev and G. I. Nepomnyashchikh, Problems of General Pathology at the End of the 20th Century[in Russian], Novosibirsk (2000).

  5. E. L. Nasonov, A. A. Baranov, and N. P. Shilkina, Vasculitises and Vasculopathies[in Russian], Yaroslavl (1999).

  6. E. L. Nasonov, A. A. Baranov, N. P. Shilkina, and Z. S. Alekberova, Vascular Disorders during Antiphospholipid Syndrome: Clinics, Diagnostics, and Therapy [in Russian], Moscow, Yaroslavl (1995).

  7. G. I. Nepomnyashchikh, V. N. Efremov, L. M. Nepomnyashchikh, and V. P. Tumanov, Byull. Eksp. Biol. Med., 100, No. 12, 744-748 (1985).

    Google Scholar 

  8. L. M. Nepomnyashchikh, I. M. Kogalovskaya, G. P. Sokolova, and V. V. Kolesnik, Histochemistry in Normal and Pathological Morphologies[in Russian], Novosibirsk (1967), pp. 175-180.

  9. T. M. Reshetnyak and Z. S. Alekberova, Ter. Arkh., 70, No. 12, 74-78 (1998).

    Google Scholar 

  10. D. S. Sarkisov, A. A. Pal'tsyn, and A. A. Adamyan, Byull. Eksp. Biol. Med., 97, No. 5, 618-621 (1984).

    Google Scholar 

  11. A. I. Strukov and V. V. Serov, Pathoanatomy[in Russian], Moscow (1979).

  12. N. N. Chapaeva, A. A. Demin, and A. E. Sulut'yan, Byull. Sib. Otd. Ros. Akad. Med. Nauk, No. 1, 101-105 (2000).

  13. V. A. Alegre and R. K. Winkelmann, J. Am. Acad. Dermatol., 19, 117-124 (1988).

    Google Scholar 

  14. C. M. Artlett, J. B. Smith, and S. A. Jimenez, Mol. Med., No. 2, 74-78 (1999).

  15. P. E. Love and S. A. Santoro, Ann. Intern. Med., 112, 628-698 (1990).

    Google Scholar 

  16. J. P. Pandey and E. C. LeRoy, Arthritis Rheum., 41, 10-15 (1998).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Ultrastructural Bases of Pathology, Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Russia

    N. N. Chapaeva, G. I. Nepomnyashchikh &  Bakarev

  2. Russian Academy of Medical Sciences

    S. V. Aidagulova

Authors
  1. N. N. Chapaeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. I. Nepomnyashchikh
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. V. Aidagulova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Bakarev
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chapaeva, N.N., Nepomnyashchikh, G.I., Aidagulova, S.V. et al. Antiphospholipid Syndrome: Ultrastructure of Microvascular Endotheliocytes in Musculocutaneous Bioptates during Systemic Lupus Erythematosus. Bulletin of Experimental Biology and Medicine 131, 176–180 (2001). https://doi.org/10.1023/A:1017508432076

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1017508432076

Search

Navigation