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Morphological Changes in Burn Wounds after Transplantation of Allogenic Fibroblasts

Bulletin of Experimental Biology and Medicine volume 131, pages 89–93 (2001)Cite this article

Abstract

Cultured allogenic fibroblasts labeled with fluorescent acridine orange and transplanted onto burn wound virtually completely disappear from the wound surface within 2 days (are destroyed). Study of wound morphology by light autoradiography and quantitative analysis showed a stimulating effect of transplanted fibroblasts on wound healing. This effect, irrespective of the initial state of the wound, is always directed at accelerated formation of connective tissue similar to the derma and capable of epithelialization.

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Affiliations

  1. Russian Academy of Medical Sciences; Speranskii Pediatric Clinical Hospital, Moscow

    E. G. Kolokol'chikova, L. I. Budkevich, A. E. Bobrovnikov, A. K. Badikova & V. P. Tumanov

  2. Speranskii Pediatric Clinical Hospital, Moscow

    L. I. Budkevich, A. E. Bobrovnikov, A. K. Badikova & V. P. Tumanov

Authors
  1. E. G. Kolokol'chikova
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  2. L. I. Budkevich
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  3. A. E. Bobrovnikov
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  4. A. K. Badikova
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  5. V. P. Tumanov
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Kolokol'chikova, E.G., Budkevich, L.I., Bobrovnikov, A.E. et al. Morphological Changes in Burn Wounds after Transplantation of Allogenic Fibroblasts. Bulletin of Experimental Biology and Medicine 131, 89–93 (2001). https://doi.org/10.1023/A:1017503301550

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  • DOI: https://doi.org/10.1023/A:1017503301550

  • fibroblast culture
  • transplantation
  • wound healing
  • autoradiography