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Effects of Transforming Growth Factor-β1 on Proliferation of Smooth Muscle Cells in Human Aortic Intima and Human Promonocytic Leukemia THP-1 Cells

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Abstract

We studied the effects of transforming growth factor on proliferation of cultured smooth muscle cells from human aortic intima and proliferation and differentiation of human leukemia THP-1 promonocytes. Transforming growth factor inhibited proliferation of these cells, but stimulated differentiation of THP-1 cells. Therefore, transforming growth factor probably modulates proliferation and differentiation of smooth muscle cells and monocytes/macrophages involved in the pathogenesis of atherosclerotic damages.

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Kalinina, N.I., Ilyinskaya, O.P., Bobik, A. et al. Effects of Transforming Growth Factor-β1 on Proliferation of Smooth Muscle Cells in Human Aortic Intima and Human Promonocytic Leukemia THP-1 Cells. Bulletin of Experimental Biology and Medicine 131, 162–164 (2001). https://doi.org/10.1023/A:1017500230259

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  • DOI: https://doi.org/10.1023/A:1017500230259

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