Abstract
We studied the effects of transforming growth factor on proliferation of cultured smooth muscle cells from human aortic intima and proliferation and differentiation of human leukemia THP-1 promonocytes. Transforming growth factor inhibited proliferation of these cells, but stimulated differentiation of THP-1 cells. Therefore, transforming growth factor probably modulates proliferation and differentiation of smooth muscle cells and monocytes/macrophages involved in the pathogenesis of atherosclerotic damages.
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REFERENCES
N. I. Kalinina, P. Kanellakis, O. P. Il'yinskaya, et al., Arterial'naya Gipertenziya, 51, No. 1, 29-30 (1999).
N. I. Kalinina, E. M. Tararak, O. P. Il'yinskaya, et al., Atherosclerosis, 151, No. 1, 29 (2000).
A. Agrotis, M. Condron, and A. Bobik, FEBS Lett., 467, No. 1, 128-132 (2000).
A. Bobik, A. Agrotis, P. Kanellakis, et al., Circulation, 99, 2883-2891 (1999).
C. Bombara and R. A. Ignotz, J. Cell Physiol., 153, No. 1, 30-37 (1992).
P. J. De Bleser, T. Niki, V. Rogiers, and A. Geerts, J. Hepatol., 26, No. 4, 886-893 (1997).
M. Hitomi, J. Shu, A. Agarwal, and D. W. Stacey, Oncogene, 17, No. 8, 959-969 (1998).
J. Massague, Annu. Rev. Biochem., 67, 753-791 (1998).
A. N. Orekhov, V. A. Kosykh, V. S. Repin, and V. N. Smirnov, Lab. Invest., 48, 749-757 (1983).
K. Pardali, A. Kurisaki, A. Moren, et al., J. Biol. Chem., 275, No. 38, 29,244-29,256 (2000).
J. Saltis, Mol. Cell Endocrinol., 116, No. 2, 227-232 (1996).
J. F. Tsai, L. Y. Chuang, J. E. Jeng, et al., Medicine (Baltimore), 76, No. 3, 213-226 (1997).
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Kalinina, N.I., Ilyinskaya, O.P., Bobik, A. et al. Effects of Transforming Growth Factor-β1 on Proliferation of Smooth Muscle Cells in Human Aortic Intima and Human Promonocytic Leukemia THP-1 Cells. Bulletin of Experimental Biology and Medicine 131, 162–164 (2001). https://doi.org/10.1023/A:1017500230259
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DOI: https://doi.org/10.1023/A:1017500230259