Towards therapeutic applications of Kv1 channel blockers in neurological diseases


Potassium channels are involved at several stages in inflammatory neuropathies by inducing conduction blocks in demyelinated axons and by taking part in cytokines secretion by activated immunitary cells. Blockers of these channels are therefore potential candidates for the symptomatic treatment of these neuropathies, through their immunosuppressive and neurological effects. This review aims at evaluating the possible therapeutic use of highly selective potassium channel blockers derived from natural toxins.

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Crest, M., Beraud-Juven, E. & Gola, M. Towards therapeutic applications of Kv1 channel blockers in neurological diseases. Perspectives in Drug Discovery and Design 15, 333–342 (1999).

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  • inflammatory neuropathies
  • multiple sclerosis
  • potassium channels
  • toxins