Towards therapeutic applications of Kv1 channel blockers in neurological diseases

Abstract

Potassium channels are involved at several stages in inflammatory neuropathies by inducing conduction blocks in demyelinated axons and by taking part in cytokines secretion by activated immunitary cells. Blockers of these channels are therefore potential candidates for the symptomatic treatment of these neuropathies, through their immunosuppressive and neurological effects. This review aims at evaluating the possible therapeutic use of highly selective potassium channel blockers derived from natural toxins.

This is a preview of subscription content, access via your institution.

References

  1. 1.

    Gutman, G. A. and Chandy, K. G., Seminar Neurosci., 5 (1993) 101.

    Google Scholar 

  2. 2.

    Horackova, M., Nonner, W. and Stämpfli, R., Proc. Int. Union Physiol. Sci., 7 (1968) 198.

    Google Scholar 

  3. 3.

    Chiu, S. Y., Ritchie, J. M., Rogart, R. B. and Stagg, D., J. Physiol., 292 (1979) 149.

    Google Scholar 

  4. 4.

    Brismar, T., J. Physiol., 298 (1980) 171.

    Google Scholar 

  5. 5.

    Bostock, H., Sherratt, R. M. and Sears, T. A., Nature, 274 (1978) 385.

    Google Scholar 

  6. 6.

    Chiu, S. Y. and Ritchie, J. M., J. Physiol., 313 (1981) 415.

    Google Scholar 

  7. 7.

    Beckh, S. and Pongs, O., EMBO J., 9 (1990) 777.

    Google Scholar 

  8. 8.

    Wang, H., Kunkel, D., Martin, T., Schwartzkroin, P. A. and Tempel, B. L., Nature, 365 (1993) 75.

    Google Scholar 

  9. 9.

    Sheng, M., Tsaur, M.-L., Jan, Y. N. and Jan, L. Y., J. Neurosci., 14 (1994) 2408.

    Google Scholar 

  10. 10.

    McNamara, N. M. C., Averill, S., Wilkin, G. P., Dolly, J. O. and Priestley, J. V., Eur. J. Neurosci., 8 (1996) 688.

    Google Scholar 

  11. 11.

    Veh, R. W., Lichtinghagen, R., Sewing, S., Wunder, F., Grumbach, I. M. and Pongs, O., Eur. J. Neurosci., 7 (1995) 2189.

    Google Scholar 

  12. 12.

    Mi, H., Deering, T. J., Ellisman, M. H. and Schwartz, T. L., J. Neurosci., 15 (1995) 3761.

    Google Scholar 

  13. 13.

    Stephanova, D. I. and Chobanova, M., Biol. Cybern., 76 (1997) 311.

    Google Scholar 

  14. 14.

    Bostock, H., Sears, T. A. and Sherratt, R. M., J. Physiol., 313 (1981) 301.

    Google Scholar 

  15. 15.

    Targ, E. and Kocsis, J. D., Brain Res., 328 (1985) 358.

    Google Scholar 

  16. 16.

    Stühmer, W., Ruppersberg, J. P., Schröter, K. H., Sakmann, B., Stocker, M., Giese, K. P., Perschke, A., Baumann, A. and Pongs, O., EMBO J., 8 (1989) 3235.

    Google Scholar 

  17. 17.

    Gallin, E. K., Physiol. Rev., 71 (1991) 775.

    Google Scholar 

  18. 18.

    Lewis, R. S. and Cahalan, M. D., Annu. Rev. Immunol., 13 (1995) 623.

    Google Scholar 

  19. 19.

    Grissmer, S., Dethlefs, B., Wasmuth, J. J., Goldin, A. L., Gutman, G. A., Cahalan, M. D. and Chandy, G., Proc. Natl. Acad. Sci. USA, 87 (1990) 9411.

    Google Scholar 

  20. 20.

    Attali, B., Romey, G., Honoré, E., Schmidt-Aliana, A., Mattéi, M.G., Lesage, F., Ricard, P., Barhanin, J. and Lazdunski, M., J. Biol. Chem., 267 (1992) 8650.

    Google Scholar 

  21. 21.

    Grissmer, S., Ghanshani, S., Dethlefs, B., McPherson, J. D., Wasmuth, J. J., Gutman, G. A., Cahalan, M. D. and Chandy, K. G., J. Biol. Chem., 267 (1992) 20971.

    Google Scholar 

  22. 22.

    Wonderlin, W. F. and Strobl, J. S., J. Membr. Biol., 154 (1996) 91.

    Google Scholar 

  23. 23.

    Koo, G.C., Blake, J. T., Talento, A., Nguyen, M., Lin, S., Sirotina, A., Shah, K., Mulvany, K., Hora, D., Cunningham, P., Wunderler, D. L., McManus, O. B., Slaughter, R., Bugianesi, R., Felix, J., Garcia, M., Williamson, J., Kaczorowski, G., Sigal, N. H., Springer, M. S. and Feeney, W., J. Immunol., 158 (1997) 5120.

    Google Scholar 

  24. 24.

    Huitdehaag, B.M. J., Polman, C. H., de Groot, C. J. A. and Dijkstra, C. D., Acta Neurol. Scand., 90 (1994) 299.

    Google Scholar 

  25. 25.

    Pender, M. P. and Sears, T. A., Brain, 107 (1984) 699.

    Google Scholar 

  26. 26.

    Noseworthy, J. H., Curr. Opin. Neurosurg., 6 (1993) 209.

    Google Scholar 

  27. 27.

    Polman, C. H. and Hartung, H. P., Curr. Opin. Neurol., 8 (1995) 200.

    Google Scholar 

  28. 28.

    Schwid, S. R., Petrie, M. D., McDermott, M. P., Rierney, D. S., Mason, D. H. and Goodman, A. D., Neurology, 48 (1997) 817.

    Google Scholar 

  29. 29.

    Bethge, E. W., Bohuslavizki, K. H., Hänsel, W., Kneip, A. and Koppenhöfer, E., Gen. Physiol. Biophys., 10 (1991) 225.

    Google Scholar 

  30. 30.

    Grissmer, S., Nguyen, A., Aiyar, J., Hanson, D. C., Mather, R. J., Gutman, G. A., Karmilowicz, M. J., Auperin, D. D. and Chandy, G., Mol. Pharmacol., 45 (1994) 1227.

    Google Scholar 

  31. 31.

    Crest, M., Jacquet, G., Gola, M., Zerrouk, H., Benslimane, A., Rochat, H., Mansuelle, P. and Martin-Eauclaire, M. F., J. Biol. Chem., 267 (1992) 1640.

    Google Scholar 

  32. 32.

    Miller, C., Neuron, 15 (1995) 5.

    Google Scholar 

  33. 33.

    Dauplais, M., Lecoq, A., Song, J., Cotton, J., Jamin, N., Gilquin, B., Roumestand, C., Vita, C., de Meideros, C., Rowan, E. G., Harvey, A. L. and Ménez, A., J. Biol. Chem., 272 (1997) 4302.

    Google Scholar 

  34. 34.

    Cotton, J., Crest, M., Bouet, F., Alessandri, N., Gola, M., Forest, E., Karlsson, E., Castaneda, O., Harvey, A. L., Vita, C. and Ménez, A., Eur. J. Biochem., 244 (1997) 192.

    Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Crest, M., Beraud-Juven, E. & Gola, M. Towards therapeutic applications of Kv1 channel blockers in neurological diseases. Perspectives in Drug Discovery and Design 15, 333–342 (1999). https://doi.org/10.1023/A:1017057316654

Download citation

  • inflammatory neuropathies
  • multiple sclerosis
  • potassium channels
  • toxins