Skip to main content
SpringerLink
Log in

Modern Views of Prenatal Morphogenesis of Human Lung

  • Published:
Russian Journal of Developmental Biology Aims and scope Submit manuscript

Abstract

Published and original data on human lung morphogenesis during prenatal development are reviewed. Morphofunctional description of the lung at various phases of prenatal morphogenesis is given. Differentiation of various lung structures, surfactant system, development of pulmonary fluid, and the onset of breathing movements of the fetus are considered in chronological order. The “critical periods” when the fetal respiratory organs are most sensitive to unfavorable factors are considered. Morphofunctional tests for lung maturity applicable for predicting lung pathology of human fetus are described.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  • Adamson, I.Y.R., Development of Lung Structure, The Lung: Scientific Foundations, Crystal, R.G. et al., Eds., New York: Raven, 1991, vol. 1, pp. 663-670.

    Google Scholar 

  • Avery, M.E. and Mead, J., Surface Properties in Relation to Atelectasis and Hyaline Membrane Disease, Am. J. Dis. Child, 1959, vol. 97, pp. 517-523.

    Google Scholar 

  • Barth, P.J., Wolf, M., and Ramaswamy, A., Distribution and Number of Clara Cells in the Normal and Disturbed Development of the Human Fetal Lung, Pediatr. Pathol., 1994, vol. 14, no. 4, pp. 637-653.

    Google Scholar 

  • Bland, R.D., Fetal Lung Liquid and Its Removal Near Birth, The Lung: Scientific Foundations, Crystal, R.G. et al., Eds., New York: Raven, 1991, pp. 1677-1685.

    Google Scholar 

  • Blinova, S.A., Neuroendocrine System of Respiratory Organs, Kletochnaya biologiya legkikh v norme i pri patologii (Cell Biology of the Lung in the Norm and Pathology), Erokhin, V.V. and Romanova, L.K., Eds., 2000, Moscow: Meditsyna, pp. 221-234.

    Google Scholar 

  • Boyden, E.A., Development and Growth of the Airways, Development of the Lung, Nodson, W.A., Ed., New York: Marcel Dekker, 1977, pp. 3-36.

    Google Scholar 

  • Bucher, U. and Reid, L.M., Development of the Mucus-Secreting Elements in Human Lung, Thorax, 1961, vol.16, pp. 219-225.

    Google Scholar 

  • Burri, P.H., Postnatal Development and Growth, The Lung: Scientific Foundations, Crystal, R.G. et al., Eds., New York: Raven, 1991, vol. 1, pp. 677-687.

    Google Scholar 

  • Campiche, M.A., Gautier, A., Mernandez, E.I., and Reymond, A., An Electron Microscope Study of the Fetal Development of Human Lung, Pediatrics, 1963, vol. 32, pp. 976-994.

    Google Scholar 

  • Carlson, B.M., Patten's Foundations of Embryology, New York: McGraw-Hill, 1988.

    Google Scholar 

  • Farrell, P.M., Overview of Hyaline Membrane Disease, Lung Development: Biological and Clinical Perspectives, Farrell, P., Ed., New York: Academic, 1982, pp. 23-46.

    Google Scholar 

  • Faure-Fremiet, E. and Dragiou, J., Le Developement du Poumon Foetal chez la Mouton, Arch. Anat. Microsc., 1923, vol. 19, pp. 411-424.

    Google Scholar 

  • Harding, R., Fetal Breathing Movements, The Lung: Scientific Foundations, Crystal, R.G. et al., Eds., New York: Raven, 1991, vol. 2, pp. 1655-1665.

    Google Scholar 

  • Jeffery, P.K. and Reid, L.M., Ultrastructure of Airway Epithelium and Submucosal Gland during Development, Development of Lung, Hodson, W.A., Ed., New York: Marsel Dekker, 1977, pp. 87-134.

    Google Scholar 

  • Jost, A. and Policard, A., Contribution Experimental a l'Etude du Developement Prenatal du Poumon chez le Lapin, Arch. Anat. Microsc., 1948, vol. 37, pp. 323-332.

    Google Scholar 

  • Kauffman, Sh.L., Cell Proliferation in the Mammalian Lung, Int. Rev. Exp. Path., 1980, vol. 22, pp. 131-191.

    Google Scholar 

  • Kaufman, O.Ya., Gusev, S.A., and Orekhov, O.O., Blood and Lymphatic Systems of the Lung, Kletochnaya biologiya legkikh v norme i pri patologii (Cell Biology of the Lung in the Norm and Pathology), Erokhin, V.V. and Romanova, L.K., Eds., 2000, Moscow: Meditsyna, pp. 181-207.

    Google Scholar 

  • Kleimenova, N.V., The Role of Condition of the Pulmonary Surfactant in Development of Respiratory Diseases, Cand. Sci. (Biol.) Dissertation, Moscow, 1986.

  • Kovalenko, L.V., Condition of Fetal Lung Surfactant System during Experimental Diabetes Mellitus in Pregnant Women, Doctoral (Med.) Dissertation, Simferopol: Krym. Med. In-t, 1997.

    Google Scholar 

  • Langston, C., Kida, K., Reed, M., and Thurlbeck, W.M., Human Lung Growth in Late Gestation and in the Neonate, Am. Rev. Respir. Dis., 1984, vol. 129, pp. 607-613.

    Google Scholar 

  • Le Fuk Fat, Surfactant Condition by Comparison with Immature Lung Morphological Properties, Cand. Sci. (Med.) Dissertation, Simferopol: Krym. Med. In-t, 1988.

    Google Scholar 

  • Mendelson, C.R., Johnston, M.J., MacDonald, P.C., and Snyder, J.M., Multihormonal Regulation of Surfactant Synthesis by Human Fetal Lung in vitro, J. Clin. Endocrinol. Metab., 1981, vol. 53, pp. 307-317.

    Google Scholar 

  • Perelman, R.H., Farrell, P.M., Engle, M.J., and Kemnitz, J.W., Developmental Aspects of Lung Lipids, Annu. Rev. Physiol., 1985, vol. 47, pp. 803-822.

    Google Scholar 

  • Puzyreva, N.I., Laryushkina, N.K., and Ryzhkova, N.K., Sindrom dykhatel'nykh rasstroistv i surfaktant legkikh u novorozhdennykh (Respiratory Diseases Syndrome and Pulmonary Surfactant in Newborns), Moscow: Meditsyna, 1987.

    Google Scholar 

  • Relier, J.P., Poumon Foetal et Maturation Pulmonaire, Rev. Pediatr., 1981, vol. 17, no. 8, pp. 445-461.

    Google Scholar 

  • Romanova, L.K., Regulyatsiya vosstanovitel'nykh protsessov (Regulation of Repair Processes), Moscow: Mosk. Gos. Univ., 1984.

    Google Scholar 

  • Romanova, L.K., Respiratory System, Strukturnye osnovy adaptatsii i kompensatsii narushennykh funktsii (Structural Bases of Adaptation and Compensation of Disturbed Functions), Moscow: Meditsyna, 1987, pp. 263-284.

    Google Scholar 

  • Romanova, L.K., Surfactant System of the Lung, Fiziologiya dykhaniya. Osnovy sovremennoi fiziologii (Physiology of Respiration. Bases of Modern Physiology), Breslava, I.S. and Isaeva, G.G., Eds., Petersburg: Nauka, 1994, pp. 31-53.

    Google Scholar 

  • Romanova, L.K. and Zhorova, E.S., Effects of Low Dose Radiation on Human Embryos and Fetuses, Ontogenez, 1994, vol. 25, no. 3, pp. 55-65.

    Google Scholar 

  • Romanova, L.K., Van'ko, L.V., Timoshchuk, O.A., et al., Cellular Bases of Local Immune Reactions in Human Fetal Lung, Morfologiya, 1992, vol. 102, no. 3, pp. 117-119.

    Google Scholar 

  • Romanova, L.K., Pokrovskaya, M.S., Mladkovskaya, T.B., et al., Specific Prenatal Ontogenesis of Human Lung in the Zone of Radiation Effect after Breakdown at Chernobyl Nuclear Plant, At. Energ., 1997, vol. 28, no. 1, pp.41-48.

    Google Scholar 

  • Romanova, L.K., Pokrovskaya, M.S., Mladkovskaya, T.B., et al., Morphological Description of Embryonic and Fetal Lung from the Mothers Living at the Territory Polluted by Radionuclides after Breakdown at Chernobyl Nuclear Plant, Arkh. patologii, 1998, no. 5, pp. 32-36.

  • Rousseau-Merk, M.F., Wyllie, L., Basset, F., and Nezelof, C., In vitro Behavior of Human Fetal Lung Maintained in Organ Culture, Virchows Arch. Path. Anat. Histol., 1976, vol. 371, pp. 305-321.

    Google Scholar 

  • Safonov, V.A., Eksler, N.D., and Pelevinov, V.A., Establishment of Respiratory System Function during Ontogenesis, Biol. Nauki, 1983, no. 12, pp. 4-22.

  • Scheuermann, D.W., Neuroendocrine Cells, The Lung: Scientific Foundations, Crystal, R.G. et al., Eds., New York: Raven, 1991, vol. 1, pp. 289-301.

    Google Scholar 

  • Shishkin, G.S., Soboleva, A.D., and Valitskaya, R.I., Lung Development during Embryonic and Postnatal Periods, Legkoe v norme (Lung in the Norm), Esipova, I.K., Ed., Novosibirsk: Nauka, 1975, pp. 151-174.

    Google Scholar 

  • Skinner, S., Ashby, C.A., Low, C., et al., The Growth of Fetal Lung Structures in vitro Is Stimulated by Simulated Fetal Breathing Movements, Advances in fetal physiology, Gluckman, P.D. et al., Eds., Ithaca: Perinatology, 1989, pp. 153-175.

    Google Scholar 

  • Svetlov, P.G., Theory of Critical Periods of Development and Its Significance for Understanding the Principles of Environmental Effect on Ontogenesis, Voprosy tsitologii i obshchei fiziologii (Problems of Cytology and General Physiology), Moscow: USSR Academy of Sciences, 1960, pp. 263-285.

    Google Scholar 

  • Timoshchuk, O.A., Immune System Development in Human Fetal Lung, Cand. Sci. (Biol.) Dissertation, Moscow, 1991.

  • Volkova, O.V. and Pekarskii, M.I., Embriogenez i vozrastnaya gistologiya vnutrennikh organov cheloveka (Embryogenesis and Age-related Histology of Human Viscera), Moscow: Meditsyna, 1976.

    Google Scholar 

  • Walters, D.V. and Olver, R.E., The Role of Catecholamines in Lung Liquid Absorption at Birth, Pediatr. Res., 1978, vol. 12, pp. 239-242.

    Google Scholar 

  • Weibel, E.R., Design of Airways and Blood Vessels Considered as Branching Trees, The Lung: Scientific Foundations, Crystal, R.G. et al., Eds., New York: Raven, 1991, vol. 1, pp. 711-720.

    Google Scholar 

  • Zagorul'ko, A.K., Birkun, A.A., and Novikov, N., Surfaktantnaya sistema legkikh i zamestitel'naya surfaktantnaya terapiya (Surfactant System of the Lung and Substitution Surfactant Therapy), Simferopol: Krym. med. in-t MZ USSR, 1995.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Russian Academy of Sciences, Institute of Human Morphology, ul. Tsyurupy 3, Moscow, 117997, Russia

    L. K. Romanova

Authors
  1. L. K. Romanova
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Romanova, L.K. Modern Views of Prenatal Morphogenesis of Human Lung. Russian Journal of Developmental Biology 33, 201–212 (2002). https://doi.org/10.1023/A:1016838430630

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1016838430630

Search

Navigation