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Variation in Short Tandem Repeats of Human Y Chromosome

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Abstract

Nine rare (biallelic) mutations and six short tandem repeats (STR) mapping to the nonrecombining portion of the Y chromosome were genotyped in 734 males from different geographical regions inhabited by the contemporary Armenian population. The analysis of molecular variance (AMOVA) showed that 48.9% of total STR genetic variation was explained by the differences between the haplogroups isolated based on biallelic polymorphism, whereas only 1.3% of genetic variation could be attributed to the differences between the geographic groups.

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REFERENCES

  1. Jobling, M.A. and Tyler-Smith, C.T., Fathers and Sons: The Y Chromosome and Human Evolution, Trends Genet., 1995, vol. 11, no. 11, pp. 449-456.

    Google Scholar 

  2. Hammer, M.F. and Zegura, S.L., The Role of the Y Chromosome in Human Evolutionary Studies, Evolut. Anthropol., 1996, vol. 5, no. 4, pp. 116-134.

    Google Scholar 

  3. Hammer, M.F., Spurdle, A.B., Karafet, T., et al., The Geographic Distribution of Human Y-Chromosome Variation, Genetics, 1997, vol. 145, no. 3, pp. 787-805.

    Google Scholar 

  4. Hammer, M.F., Karafet, T., Rasanayagam, A., et al., Out of Africa and Back Again: Nested Cladistic Analysis of Human Y-Chromosome Variation, Mol. Biol. Evol., 1998, vol. 15, no. 4, pp. 427-441.

    Google Scholar 

  5. Thomas, M.G., Skorecki, K., Ben-Ami, H., et al., Origins of Old Testament Priests, Nature, 1998, vol. 394, pp. 138-140.

    Google Scholar 

  6. Perez-Lesaun, A., Calafell, F., Seielstad, L.M., et al., Population Genetics of Y-Chromosome Short Tandem Repeats in Humans, J. Mol. Evol., 1997, vol. 45, pp. 265-270.

    Google Scholar 

  7. Perez-Lesaun, A., Calafell, F., Comas, D., et al., Sex-Specific Migration Patterns in Central Asian Populations, Revealed by Analysis of Y-Chromosome Short Tandem Repeats and mtDNA, Am. J. Hum. Genet., 1999, vol. 65, no. 1, pp. 208-219.

    Google Scholar 

  8. Thomas, M.G., Parfitt, T., Weiss, D.A., et al., Y-Chromosome Travelling South: The Cohen Modal Haplotype and the Origins of the Lemba, the Black Jews of Southern Africa, Am. J. Hum. Genet., vol. 66, no. 2, pp. 674-686.

  9. Hammer, M.F., A Recent Insertion of an Alu Element on the Y Chromosome Is a Useful Marker for Human Population Studies, Mol. Biol. Evol., 1994, vol. 11, pp. 749-761.

    Google Scholar 

  10. Su, B., Xiao, J., Underhill, P., et al., Y-Chromosome Evidence for a Northward Migration of Modern Humans into Eastern Asia during the Last Ice Age, Am. J. Hum. Genet., 1999, vol. 65, no. 6, pp. 1718-1724.

    Google Scholar 

  11. Scozzari, R., Cruciani, F., Santolamazza, P., et al., Combined Use of Biallelic and Microsatellite Y-Chromosome Polymorphisms to Infer Affinities among African Populations, Am. J. Hum. Genet., 1999, vol. 65, no. 3, pp. 829-846.

    Google Scholar 

  12. Karafet, T.M., Zegura, S.L., Posukh, O., et al., Ancestral Asian Source(s) of New World Y-Chromosome Founder Haplotypes, Am. J. Hum. Genet., 1999, vol. 64, no. 3, pp. 817-831.

    Google Scholar 

  13. Santos, F.R., Pandya, A., Tyler-Smith, C., et al., The Central Siberian Origin for Native American Y-Chromosomes, Am. J. Hum. Genet., 1999, vol. 64, no. 1, pp. 619-628.

    Google Scholar 

  14. Strachan, T. and Read, A.P., Human Molecular Genetics, Oxford: BIOS Sci., 1997.

    Google Scholar 

  15. Bowcock, A.M., Ruiz-Linares, A., Tomfohrde, J., et al., High Resolution of Human Evolutionary Trees with Polymorphic Microsatellites, Nature, 1994, vol. 368, no. 31, pp. 455-457.

    Google Scholar 

  16. Levinson, G. and Gutman, G.A., Slipped Strand Misprinting: A Major Mechanism for DNA Sequence Evolution, Mol. Biol. Evol., 1987, vol. 4, pp. 203-221.

    Google Scholar 

  17. Kayser, M., Roewer, L., Hedman, M., et al., Characteristics and Frequency of Germline Mutations at Microsatellite Loci from the Human Y Chromosome, as Revealed by Direct Observation in Father-Son Pairs, Am. J. Hum. Genet., 2000, vol. 66, no. 5, pp. 1580-1588.

    Google Scholar 

  18. Heyer, E., Puymirat, J., Dieltjes, P., et al., Estimating YChromosome Specific Microsatellite Mutation Frequencies Using Deep Rooting Pedigrees, Hum. Mol. Genet., 1997, vol. 6, no. 5, pp. 799-803.

    Google Scholar 

  19. Brinkmann, B., Klintschar, M., Neuhuber, F., et al., Mutation Rate in Human Microsatellites: Influence of the Structure and Length of the Tandem Repeat, Am. J. Hum. Genet., 1998, vol. 62, no. 6, pp. 1408-1415.

    Google Scholar 

  20. Jobling, M.A., Heyer, E., Dieltjes, P., and de Knijff, P., Y-Chromosomal Specific Microsatellite Mutation Rates Re-Examined Using a Minisatellite, MSY1, Hum. Mol. Genet., 1999, vol. 8, no. 11, pp. 2117-2120.

    Google Scholar 

  21. Zerjal, T., Dashnyam, B., Pandya, A., et al., Genetic Relationships of Asians and Northern Europeans, Revealed by Y-Chromosomal DNA Analysis, Am. J. Hum. Genet., 1997, vol. 60, no. 5, pp. 1174-1183.

    Google Scholar 

  22. Hurles, M.E., Veitia, R., Arroyo, E., et al., Recent Male-Mediated Gene Flow Over a Linguistic Barrier in Iberia, Suggested by Analysis of a Y-Chromosomal DNA Polymorphism, Am. J. Hum. Genet., 1999, vol. 65, no. 5, pp. 1437-1448.

    Google Scholar 

  23. Bosch, E., Calafell, F., Santos, F.R., et al., Variation in Short Tandem Repeats Is Deeply Structured by Genetic Background on the Human Y Chromosome, Am. J. Hum. Genet., 1999, vol. 65, no. 6, pp. 1623-1638.

    Google Scholar 

  24. Jorde, L.B., Watkins, W.S., Bamshad, M.J., et al., The Distribution of Human Genetic Diversity: A Comparison of Mitochondrial, Autosomal, and Y-Chromosome Data, Am. J. Hum. Genet., 2000, vol. 66, no. 3, pp. 979-988.

    Google Scholar 

  25. Seielstad, M.T., Minch, E., and Cavalli-Sforza, L.L., Genetic Evidence for a Higher Female Migration Rate in Humans, Nat. Genet., 1998, vol. 20, no. 3, pp. 278-280.

    Google Scholar 

  26. Yepiskoposyan, L., Weale, M.E., Jager, R.F., et al. Y chromosome Diversity in the Armenian Population,Abstr. 12th Congr. Europ. Anthropolog. Association (Cambridge, England, 8-11 September, 2000), Univ. Cambridge, 2000, pp. 37-38.

  27. Whitfild, L.S., Suitson, J.E., and Goodfellow, P.N., Sequence Variation of the Human Y Chromosome, Nature, 1995, vol. 378, no. 23, pp. 379-380.

    Google Scholar 

  28. Seielstad, M.T., Hebert, J.M., Lin, A.A., et al., Construction of Human Y-Chromosomal Haplotypes Using a New Polymorphic A to G Transition, Hum. Mol. Genet., 1994, vol. 3, no. 12, pp. 2159-2161.

    Google Scholar 

  29. Underhill, P.A., Jin, L., Lin, A.A., et al., Detection of Numerous Y Chromosome Biallelic Polymorphisms by Denaturing High-Performance Liquid Chromatography, Genome Res., 1997, vol. 7, pp. 996-1005.

    Google Scholar 

  30. Mathias, N., Bayes, M., and Tyler-Smith, C., Highly Informative Compound Haplotypes for the Human Y Chromosome, Hum. Mol. Genet., 1994, vol. 3, no. 1, pp. 115-123.

    Google Scholar 

  31. Vogt, P.H., Affara, N., Davey, P., et al., Report of the Third International Workshop on Y Chromosome Mapping, 1997, Cytogenet. Cell Genet., 1997, vol. 79, no. 1, pp. 1-20.

    Google Scholar 

  32. Ryskov, A.P., Prosnyak, M.I., Kupriyanova, N.S., et al., DNA Fingerprinting: Development of a Technology and Its Application to the Study of Human Populations, Molecular Biology and Human Diversity, Boyse, A.J. and Mascie-Taylor, C.G.N., Eds., Cambridge: Cambridge Univ. Press, 1996, pp. 29-50.

    Google Scholar 

  33. Schneider, S., Roessli, D., and Excoffier, L., Arlequin Ver. 2.000: A Software for Population Genetics Data Analysis, in Genetic and Biometry Laboratory, Geneva: Univ. Geneva, 2000.

    Google Scholar 

  34. de Knijff, P., Kayser, M., Caglia, A., et al., Chromosome Y Microsatellites: Population Genetic and Evolutionary Aspects, Int. J. Legal Med., 1997, vol. 110, pp. 134-140.

    Google Scholar 

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Authors and Affiliations

  1. Institute of Man, Yerevan, 375025, Armenia

    L. M. Yepiskoposyan, N. A. Oganesyan & A. Ts. Khudoyan

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  1. L. M. Yepiskoposyan
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  2. N. A. Oganesyan
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  3. A. Ts. Khudoyan
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Yepiskoposyan, L.M., Oganesyan, N.A. & Khudoyan, A.T. Variation in Short Tandem Repeats of Human Y Chromosome. Russian Journal of Genetics 37, 926–931 (2001). https://doi.org/10.1023/A:1016733901515

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