Skip to main content
Log in

Multiple respiratory symptoms predict quality of life in chronic lung disease: A population-based study of Australian adults

  • Published:
Quality of Life Research Aims and scope Submit manuscript

Abstract

Study objectives: Previous studies have shown that it is possible to improve the health-related quality of life (HRQoL) of chronic lung disease (CLD) patients without a concurrent change in morbidity. A valid CLD index that discriminates between different levels of CLD severity and is associated with HRQoL status is an important tool for primary care settings. In this study a symptom-based CLD index was assessed for its validity and relationship with HRQoL in a representative Australian population sample. The study also measured the prevalence of self-reported CLD. Design: Representative population survey of adults aged 18 years and over using a multistage, systematic, clustered area sample. Setting: Metropolitan Adelaide and country centres in South Australia with a population of over 1000 persons. Participants: Three hundred twenty-nine adults with CLD identified through a representative population survey of 3010 South Australians. Measurements and Results: The CLD index and the SF-36 were administered to participants to assess the association between each subscale of the CLD index with each HRQoL scale. The CLD index was also used to assess the prevalence of CLD and the distribution of severity in self-reported CLD in the South Australian population. Each symptom sub-scale of the CLD index was significantly correlated with all scales of the SF-36. The prevalence of CLD as measured by the CLD index was 7.7% (mild), 2.2% (moderate) and 1.0% (severe). Conclusions: In the Australian context the CLD index is a reliable patient interview instrument that can be used to assess the effects of CLD on general HRQoL, improve assessment, and lead to interventions for physicians and their patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Burrows B, Earle RH. Course and prognosis of chronic obstructive lung disease. A prospective study of 200 patients. N Engl J Med 1969; 280: 397–404.

    Article  PubMed  CAS  Google Scholar 

  2. Snider GL, Kory RC, Lyons HA. Grading of pulmonary function impairment by means of pulmonary function tests. Dis Chest 1967; 52: 270–274.

    Google Scholar 

  3. Prigatano GP, Wright EC, Levin D. Quality of life and its predictors in patients with mild hypoxemia and chronic obstructive pulmonary disease. Arch Intern Med 1984; 144: 1613–1619.

    Article  PubMed  CAS  Google Scholar 

  4. Mahler DA, Faryniarz K, Tomlinson D, et al. Impact of dyspnea and physiologic function on general health status in patients with chronic obstructive pulmonary disease. Chest 1992; 102: 395–401.

    PubMed  CAS  Google Scholar 

  5. Mahler DA, Weinberg DH, Wells CK, Feinstein AR. The measurement of dyspnea. Contents, interobserver agreement, and physiologic correlates of two clinical indexes. Chest 1984; 85: 751–758.

    PubMed  CAS  Google Scholar 

  6. Mahler DA, Wells CK. Evaluation of clinical methods for rating dyspnea. Chest 1988; 93: 580–586.

    PubMed  CAS  Google Scholar 

  7. Casaburi R, Patessio A, Ioli F, Zanaboni S, Donner CF, Wasserman K. Reductions in exercise lactic acidosis and ventilation as a result of exercise training in patients with obstructive lung disease. Am Rev Respir Dis 1991; 143: 9–18.

    PubMed  CAS  Google Scholar 

  8. Matthay RA, Berger H, Davies R, Loke J, Gottschalk A, Zaret BL. Improvement in cardiac performance by oral long-acting theophylline in chronic obstructive pulmonary disease. Am Heart J 1982; 104: 1022–1026.

    Article  PubMed  CAS  Google Scholar 

  9. Petty TL. The National Mucolytic Study. Results of a randomised, double-blind, placebo-controlled study of iodinated glycerol in chronic obstructive bronchitis. Chest 1990; 97: 75–83.

    PubMed  CAS  Google Scholar 

  10. Boman G, Backer U, Larsson S, Melander B, Wahlander L. Oral acetylcysteine reduces exacerbation rate in chronic bronchitis: Report of a trial organised by the Swedish Society for pulmonary diseases. Eur J Respir Dis 1983; 64: 405–415.

    PubMed  CAS  Google Scholar 

  11. Borson S, McDonald GJ, Gayle T, Deffebach M, Lakshminarayan S, Van Tuinen C. Improvement in mood, physical symptoms, and function with nortriptyline for depression in patients with chronic obstructive pulmonary disease. Psychosomatics 1992; 33: 190–201.

    PubMed  CAS  Google Scholar 

  12. Marthur PN, Powles P, Pugsley SO, McEwan PM, Moran Campbell EJ. Effect of digoxin on right ventricular function in severe chronic airflow obstruction. Ann Intern Med 1981; 95: 283–288.

    Google Scholar 

  13. Anthonisen NR, Manfreda J, Warren CPW, Hershfield ES, Harding GKM, Nelson NA. Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann Intern Med 1987; 106: 196–204.

    PubMed  CAS  Google Scholar 

  14. Mahler DA, Matthay RA, Snyder PE, Wells CK, Loke J. Sustained-release theophylline reduces dyspnea in nonreversible obstructive airway disease. Am Rev Respir Dis 1985; 131: 22–25.

    PubMed  CAS  Google Scholar 

  15. McSweeny RJ, Heaton RK, Grant I, Adams KM, Timms RM. Life quality of patients with chronic obstructive pulmonary disease. Arch Intern Med 1982; 142: 473–478.

    Article  PubMed  CAS  Google Scholar 

  16. Guyatt GH, Townsend M, Pugsley SO. Quality-of-life in patients with chronic airflow limitation. Br J Dis Chest 1987; 81: 45–54.

    Article  PubMed  CAS  Google Scholar 

  17. Ferguson GT, Cherniak RM. Management of chronic obstructive pulmonary disease. N Engl J Med 1993; 328: 1017–1022.

    Article  PubMed  CAS  Google Scholar 

  18. Stoller JK, Ferranti R, Feinstein AR. Further specification and evaluation of a new clinical index for dyspnea. Am Rev Respir Dis 1986; 134: 1129–1134.

    PubMed  CAS  Google Scholar 

  19. Guyatt GH, Berman LB, Townsend M, Pugsley SO, Chambers LW. A measure of quality of life for clinical trials in chronic lung disease. Thorax 1987; 42: 773–778.

    Article  PubMed  CAS  Google Scholar 

  20. Hajiro T, Nishimura K, Tsukino M, Ikeda A, Koyama H, Izumi T. Analysis of clinical methods used to evaluate dyspnea in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998; 158: 1185–1189.

    PubMed  CAS  Google Scholar 

  21. Selim AJ, Xinhua SR, Fincke G, Rogers W, Lee A, Kazis L. A symptom-based measure of the severity of chronic lung disease. Chest 1997; 111: 1607–1614.

    PubMed  CAS  Google Scholar 

  22. McCallum J. The New SF-36 Health Status Measure: Australian Validity Tests. Canberra: National Centre for Epidemiology and Population Health, The Australian Na-tional University, 1994.

    Google Scholar 

  23. SPSS Inc. SPSS Advanced Statistics 8.0. Chicago: SPSS Inc., 1998.

    Google Scholar 

  24. Dean AG, Dean JA, Coulombier D, et al. Epi Info Version 6: A word processing, database, and statistics program for epidemiology on microcomputers. Centers for Disease Control and Prevention, Atlanta, Georgia, USA, 1995.

    Google Scholar 

  25. Garratt AM, Ruta DA, Abdalla MI, Buckingham JK, Russell IT. The SF-36 health survey questionnaire: An outcome measure suitable for routine use within the NHS? Br Med J 1993; 306: 1440–1444.

    Article  CAS  Google Scholar 

  26. Wakefield M, Wilson DH. SF-36 Profiles for Regions of South Australia. Adelaide: Behavioural Epidemiology Unit, South Australian Health Commission, 1996.

    Google Scholar 

  27. Kazis LE, Anderson JJ, Mennan RF. Effect sizes for interpreting changes in health status. Med Care 1989; 27 (Suppl): S178–S189.

    PubMed  CAS  Google Scholar 

  28. Goldberg D, Williams P. A User's Guide to the General Health Questionnaire. Windsor: NFER-Nelson, 1998.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ruffin, R., Wilson, D., Chittleborough, C. et al. Multiple respiratory symptoms predict quality of life in chronic lung disease: A population-based study of Australian adults. Qual Life Res 9, 1031–1039 (2000). https://doi.org/10.1023/A:1016689729722

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1016689729722

Navigation