Andrology: Seasonal Changes in Human Sperm Chromatin Condensation
- 54 Downloads
Purpose: The aim of this study was to investigate possible seasonal changes in human sperm parameters, especially chromatin condensation.
Method: In a first run, 3155 patients attending the andrological outpatient clinic at the Centre of Dermatology and Andrology at Justus Liebig University, Giessen, Germany, from January 1992 to October 1995 were examined for sperm count, motility, vitality, and chromatin condensation.
Results: The respective results were correlated according to season. Significant seasonal changes were observed in chromatin condensation and sperm count, with mean maximum values (for chromatin condensation and sperm count) of 86.24% aniline blue-negative spermatozoa in January and 68.75 × 106mL−1 in April. To confirm the observation of seasonal changes in sperm chromatin condensation in Germany on the Southern Hemisphere, 179 patients attending the Reproductive Biology Unit at Tygerberg Hospital, Tygerberg, South Africa, were examined by means of the aniline blue stain from April 1999 to April 2000. For chromatin condensation, a significant seasonal change shifted by 4–5 months was observed on the Southern Hemisphere. However, no seasonal variations could be found for the sperm count.
Conclusions: Our results clearly demonstrate seasonal changes in sperm count and chromatin condensation. In contrast, no circannual relation was observed for motility and vitality.
Unable to display preview. Download preview PDF.
- 1.Dunbar RIM: Environmental and social determinants of fecundity in primates. In Fertility and Resources, J Anders, V Reynolds (eds), Cambridge, Cambridge University Press, 1990, pp 5-17Google Scholar
- 2.Becker S: Seasonality of fertility in Matlab, Bangladesh. J Biosoc 1981;13:97-105Google Scholar
- 3.Levine RJ, Mathew RM, Chenault BC, Brown MH, Hurtt ME, Bently KS: Differences in the quality of semen in outdoor workers during summer and winter. N Engl J Med 1990;323:12-16Google Scholar
- 4.Mathers CD, Harris RS: Seasonal distribution of births in Australia. Int J Epidemiol 1983;12:326-331Google Scholar
- 5.Timonen S, Franzas B, Wichmann K: Photosensitivity of the human pituitary. Ann Chir Gynaecol Fenn 1964;53:165-170Google Scholar
- 6.Jongbloet PH: The effect of preovulatory overripeness of humaneggs on development. In Aging Gametes, RJ Blandau (ed), Basel, Switzerland, S. Karger AG, pp 300-329Google Scholar
- 7.Rameshkumar K, Thomas JA, Mohammed A: Atmospheric temperature and anovulation in south Indian women with primary infertility. Ind J Med Res 1992;96:27-28Google Scholar
- 8.Rojanski N, Brzezinski A, Schenker JG: Seasonality in human reproduction: An update. Hum Reprod 1992;7:735-745Google Scholar
- 9.Stolwijk AM, Reuvers MJ, Hamilton CJ, Jongbloet PH, Hollanders JM, Zielhuis GA: Seasonality in the results of invitro fertilization. Hum Reprod 1994;9:2300-2305Google Scholar
- 10.Reinberg A, Smolensky MH, Hallek M, Smith KD, Steinberger E: Annual variation in semen characteristics and plasma hormone levels in men undergoing vasectomy. Fertil Steril 1988;49:309-315Google Scholar
- 11.Mortimer D, Templeton AA, Lenton EA, Coleman RA: Annual patterns of human sperm production and semen quality. Arch Androl 1983;10:1-5Google Scholar
- 12.Tjoa WS, Smolensky MH, Hsi BP, Steinberger E, Smith KD: Circannual rhythm in human sperm count revealed by serially independent sampling. Fertil Steril 1982;38:454-459Google Scholar
- 13.Saint Pol P, Beuscart R, Leroy-Martin B, Hermand E, Jablonski W: Circannual rhythms of sperm parameters of fertile men. Fertil Steril 1989;51:1030-1033Google Scholar
- 14.World Health Organization: WHOLaboratory Manual for the Examination of Human Semen and Semen-Cervical Mucus Interaction, 3rd edn. Cambridge, Cambridge University Press, 1992Google Scholar
- 15.Terquem A, Dadoune JP: Aniline blue staining of human spermatozoon chromatin. Evaluation of nuclear maturation. In The Sperm Cell, J André (ed), The Hague, Martinus Nijhoff Publishers, 1983, pp 249-252Google Scholar
- 16.Meriggiola MC, Noonan EA, Paulsen CA, Bremner WJ: Annual patterns of luteinizing hormone, follicle stimulating hormone, testosterone and inhibin in normal men. Hum Reprod 1996;11:248-252Google Scholar
- 17.Brzezinski A, Wurtman RJ: The pineal gland: Its possible roles in human reproduction. Obstet Gynecol Surv 1988;43:197-207Google Scholar
- 18.Stetson MH, Matt KS, Watson-Whitmyre M: Photoperiodism and reproduction in Golden hamsters: Circadian organisation and the termination of photorefractoriness. Biol Reprod 1976;14:531-537Google Scholar
- 19.Olivares AN, Valladares LE, Bustos-Obregon E, Nunez SM: Testicular function of sexually immature rats chronically treated with melatonin. Arch Biol Med Exp Santiago 1989;22:387-393Google Scholar
- 20.Oko RJ, Jando V, Wagner CL, Kistler WS, Hermo LS: Chromatin reorganization in rat spermatids during the disappearance of testis-specific histone, H1t, and the appearance of transition proteins TP1 and TP2. Biol Reprod 1996;54:1141-1157Google Scholar
- 21.Janecki A, Jakubowiak A, Steinberger A: Regulation of transepithelial electrical resistance in two-compartment Sertoli cell cultures: In vitro model of the blood-testis barrier. Endocrinology 1991;129:1489-1496Google Scholar
- 22.Auger J, Mesbah M, Huber C, Dadoune JP: Aniline blue staining as a marker of sperm chromatin defects associated with different semen characteristics between proven fertile and suspected infertile men. Int J Androl 1990;13:452-462Google Scholar
- 23.Hammadeh ME, Stieber M, Haidl G, Schmidt W: Association between sperm cell chromatin condensation, morphology based on strict criteria, and fertilization, cleavage and pregnancy rates in an IVF program. Andrologia 1998;30:29-35Google Scholar
- 24.Henkel R, Franken DR, Lombard CJ, Schill W-B: The selective capacity of glass wool filtration for normal chromatin condensed human spermatozoa: A possible therapeutic modality for male factor cases? J Assist Reprod Genet 1994;11:395-400Google Scholar
- 25.Sánchez R, Peña P, Miska W, Henkel R: Determination de la variabilidad en la condensación de la cromatina espermatica y ?-glucosidasa seminal en relación al espermiograma. Rev Med Chil 2000;128:483-489Google Scholar