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Surface-modified 3D scaffolds for tissue engineering

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Abstract

The aim of this work was to use sol–gel processing to develop bioactive materials to serve as scaffolds for tissue engineering that will allow the incorporation and release of proteins to stimulate cell function and tissue growth. We obtained organofunctionalized silica with large content of amine and mercaptan groups (up to 25%). The developed method can allow the incorporation and delivery of proteins at a controlled rate. We also produced bioactive foams with binary SiO2–CaO and ternary SiO2–CaO–P2O5 compositions. In order to enhance peptide–material surface properties, the bioactive foams were modified with amine and mercaptan groups. These materials exhibit a highly interconnected macroporous network and high surface area. These textural features together with the incorporation of organic functionally groups may enable them to be used as scaffolds for the engineering of soft tissue.

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Authors and Affiliations

  1. Department of Metallurgical and Materials Engineering, Federal University of Minas Gerais, Rua Espírito Santo, 35 - 2 ° andar -30160-030, Belo Horizonte, MG, Brazil

    R. F. S. Lenza & W. L. Vasconcelos

  2. Imperial College of Science, Technology and Medicine, Centre for Tissue Engineering and Repair, Department of Materials, Prince Consort Road, London, SW7 2BP, UK

    J. R. Jones & L. L. Hench

Authors
  1. R. F. S. Lenza
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  2. W. L. Vasconcelos
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  3. J. R. Jones
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  4. L. L. Hench
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Correspondence to R. F. S. Lenza.

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Lenza, R.F.S., Vasconcelos, W.L., Jones, J.R. et al. Surface-modified 3D scaffolds for tissue engineering. Journal of Materials Science: Materials in Medicine 13, 837–842 (2002). https://doi.org/10.1023/A:1016592127407

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