Abstract
Mutual catalytic effects within the Salt-Induced Peptide Formation (SIPF) Reaction might be one little puzzle piece in the complicated process of the formation of complex peptidic systems and their chemical evolution on the prebiotic earth. The catalytic effects of glycine and diglycine on the formation of dipeptides from mixed amino acid systems in the SIPF Reaction was investigated for systems with leucine, proline, valine and aspartic acid and showed to result in a significant increase of the yield of the majority of the produced dipeptides. The results of the experiments strongly confirm previous theories on the catalytic mechanism and show the ability of the SIPF Reaction to produce a very diverse set of peptide products with relevance to the formation of a biosphere.
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References
Carver, J. H.: 1981, Prebiotic Atmospheric Oxygen Levels, Nature 292, 136–138.
Cloud, P.: 1973, Paleoecological Significance of the Banded Iron Formation, Econ. Geol. 68, 1135–1143.
Eder, A. H. and Rode, B. M.: 1994, Influence of Alkali-and Alkaline-earth-metal Cations on the 'Salt-induced Peptide Formation' Reaction, J. Chem. Soc. Dalton Trans. 7, 1125–1130.
Karplus, P. A.: 1997, Hydrophobicity Regained, Protein Sci. 6, 1302–1307.
Levine, J. S., Augustsson, T. R. and Natarajan, M.: 1982, The Pre-biological Paleoatmosphere: Stability and Composition, Origins Life 12, 245–259.
Liedl, K. R. and Rode, B. M.: 1992, Ab Initio Calculations Concerning the Reaction Mechanism of the Copper(II) Catalyzed Glycine Condensation in Aqueous Sodium Chloride Solution, Chem. Phys. Lett. 197, 181–186.
Limtrakul, J. P., Fujiwara, S. and Rode, B. M.: 1985, A Quantum Chemical Analysis of the Structural Entities in Aqueous Sodium Chloride Solution and their Concentration Dependence, Anal. Sci. 1, 29–32.
Limtrakul, J. P. and Rode, B. M.: 1985, Solvent Structures around Sodium and Chloride Ions in Water, Mh. Chem. 116, 1377–1384.
Miller, S. L., Urey, H. C. and Oro, J.: 1976, Origin of Organic Compounds on the Primitive Earth and in Meteorites, J. Mol. Evol. 9, 59–72.
Ochiai, E.: 1978, The Evolution of the Environment and its Influence on the Evolution of Life, Origins Life 9, 81–91.
Oie, T., Loew, G. H., Burt, S. K., Binkley, J. S. and MacElroy, R. D.: 1982, Quantum Chemical Studies of a Model for Peptide Bond Formation: Formation of Formamide and Water from Ammonia and Formic Acid, J. Am. Chem. Soc. 104, 6169–6174.
Oie, T., Loew, G. H., Burt, S. K. and MacElroy, R. D.: 1983, Quantum Chemical Studies of a Model for Peptide Bond Formation. 2. Role of Amine Catalyst in Formation of Formamide and Water from Ammonia and Formic Acid, J. Am. Chem. Soc. 105, 2221–2227.
Oie, T., Loew, G. H., Burt, S. K. and MacElroy, R. D.: 1984, Quantum Chemical Studies of a Model for Peptide Bond Formation. 3. Role of Magnesium Cation in Formation of Amide and Water from Ammonia and Glycine, J. Am. Chem. Soc. 106, 8007–8013.
Schwendinger, M. and Rode, B. M.: 1989a, Monte Carlo Simulation of a Supersaturated Sodium Chloride Solution, Chem. Phys. Lett. 155, 527–532.
Schwendinger, M. G. and Rode, B. M.: 1989b, Possible Role of Copper and Sodium Chloride in Prebiotic Evolution of Peptides, Anal. Sci. 5, 411–414.
Schwendinger, M. G. and Rode, B. M.: 1992, Investigations on the Mechanism of the Salt-Induced Peptide Formation Reaction, Origins Life Evol. Biosphere 22, 349–359.
Suwannachot, Y. and Rode, B. M.: 1998, Catalysis of Dialanine Formation by Glycine in the Salt-Induced Peptide Formation Reaction, Origins Life Evol. Biosphere 28, 79–90.
Suwannachot, Y. and Rode, B. M.: 1999, Mutual Amino Acid Catalysis in Salt Induced Peptide Formation Supports this Mechanism's Role in Prebiotic Peptide Evolution, Origins Life Evol. Biosphere 29, 463–471.
Tauler, R. and Rode, B. M.: 1990, Reactions of Cu(II) with Glycine and Glycylglycine in Aqueous Solution at High Concentrations of Sodium Chloride, Inorg. Chim. Acta 173, 93–98.
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Plankensteiner, K., Righi, A. & Rode, B.M. Glycine and Diglycine as Possible Catalytic Factors in the Prebiotic Evolution of Peptides. Orig Life Evol Biosph 32, 225–236 (2002). https://doi.org/10.1023/A:1016523207700
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DOI: https://doi.org/10.1023/A:1016523207700