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In Vitro Antimicrobial Activity of Benzoquinolinediones

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Abstract

The in vitro antibacterial and anti-fungal activity of benz[g]isoquinoline-5,10-dione (1), benzo[g]quinoline-5, 10-dione (2), benzo[g]quinoline-5,6-dione (3), and anthraquinone (4) was determined using the agar well-diffusion assay. The minimum inhibitory concentrations (MIC's) of each of the active compounds (1–3) was determined using the two-fold serial dilution technique. Of the four compounds tested, benz[g]isoquinoline-5,10-dione exhibited the best overall activity against both bacteria and fungi. Particularly noteworthy was its significant antifungal activity which was comparable to the activity of the standard antifungal antibiotic amphotericin B.

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Authors and Affiliations

  1. Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, MS, 38677

    Alice M. Clark

  2. Division of Analytical Chemistry, Oak Ridge National Laboratory, Oak Ridge, TN, 37830

    Cheng Yu Ma

Authors
  1. Alice M. Clark
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  2. Debra L. Huddleston
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  3. Cheng Yu Ma
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  4. Chuen-Huei Ho
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Clark, A.M., Huddleston, D.L., Ma, C.Y. et al. In Vitro Antimicrobial Activity of Benzoquinolinediones. Pharm Res 1, 269–271 (1984). https://doi.org/10.1023/A:1016398003032

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  • DOI: https://doi.org/10.1023/A:1016398003032

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