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Radioiodinated Cholesteryl lopanoate as a Potential Probe for the in Vivo Visualization of Atherosclerotic Lesions in Animals

Pharmaceutical Research volume 3, pages 52–55 (1986)Cite this article

Abstract

Radioiodinated cholesteryl iopanoate, a nonhydrolyzable cholesteryl ester probe, showed increased uptake into atherosclerotic aortas of cholesterol-fed rabbits in comparison with normal rabbits. Auto-radiography of the aortas showed the radioactivity to be concentrated in areas of visible atherosclerotic involvement. Lipid extraction and thin-layer chromatography of this tissue as well as liver, adrenal, and plasma confirmed the resistance of this probe to hydrolysis. These findings suggest that 125I-cholesteryl iopanoate may prove useful for noninvasively monitoring atherosclerosis in intact laboratory animals.

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Affiliations

  1. Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, 48109-0010

    Mark R. De Galan, Susan W. Schwendner, Jamey P. Weichert & Raymond E. Counsell

Authors
  1. Mark R. De Galan
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  2. Susan W. Schwendner
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  3. Jamey P. Weichert
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  4. Raymond E. Counsell
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De Galan, M.R., Schwendner, S.W., Weichert, J.P. et al. Radioiodinated Cholesteryl lopanoate as a Potential Probe for the in Vivo Visualization of Atherosclerotic Lesions in Animals. Pharm Res 3, 52–55 (1986). https://doi.org/10.1023/A:1016376916448

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  • DOI: https://doi.org/10.1023/A:1016376916448

  • radioiodinated cholesteryl iopanoate
  • nonhydrolyzable cholesteryl ester probe
  • atherosclerosis
  • rabbit