Abstract
Objective.Several studies suggest that parameters derivedfrom bispectral analysis of the EEG can be used to characterize specificcortical activation states represented by non linear interaction betweenbrain electrical oscillations. For example, it was shown that so-calledbispectral indices can be used to assess the depth of sedation. Themethods applied so far are based on interval-related procedures ofbispectral analysis. Consequently, the use of the resulting parametersfor on-line monitoring or investigations of signal properties duringtransition periods, e.g., when entering burst-suppression periods, isrestricted. The objective of this paper is to provide the methodologicalbasis for a time-continuous (on-line) investigation of quadratic phasecoupling induced by amplitude modulation. Methods.To accomplishthis aim an algorithm is presented which enables the analysis of thetemporal development in the degree of amplitude modulation (DAM), e.g.,during the transition to burst-suppression periods in patients withsevere neurological diseases. Results.It was found that theseperiods are associated with increasing DAM compared with the baselineconditions.
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Arnold, M., Witte, H. & Schelenz, C. Time-Variant Investigation of Quadratic Phase Couplings Caused by Amplitude Modulation in Electroencephalic Burst-Suppression Patterns. J Clin Monit Comput 17, 115–123 (2002). https://doi.org/10.1023/A:1016362209175
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DOI: https://doi.org/10.1023/A:1016362209175