Abstract
Characteristics of the distribution of 31 HLA antigens of classes I (A, B, and Cw) and II (DR) in Nagornyi Karabakh Armenians are reported for the first time. It has been found that the antigens most common in this population are A2, A3, A9, B5, B7, B12, Cw4, DR4, DR2, and DR3; the least common antigens are B15, B16, and B40. The results are compared with the data for Armenians living in Armenia and those for major ethnic groups. The frequencies of HLA antigens in Nagornyi Karabakh Armenians match those in Armenians living in Armenia. In the HLA-antigen distribution, Armenians are generally close to Caucasoids.
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REFERENCES
Nersisyan, V.M., Delanyan, R.Z., Danielyan, I.B., and Badunts, N.Ya., Specific Features of the Phenotype and Gene Frequency Distributions of the AB0 and AVO Rhesus Systems in the Nagornyi Karabakh Population, Genetika (Moscow), 1994, vol. 30, no. 2, pp. 271-273.
Nersisyan, V.M., Martirosyan, I.G., and Musaelyan, N.O., A Study of Immunogenetic Markers of Erythrocytic Systems in Armenians of Nagornyi Karabakh, Genetika (Moscow), 1998, vol. 34, no. 8, pp. 1134-1137.
Snell, J., Dosse, G., and Netensen, S., Sovmestimost' tkanei (Tissue Compatibility), Moscow: Mir, 1979.
Prokop, O. and Geler, V., Gruppy krovi cheloveka (Human Blood Groups), Moscow: Meditsina, 1991.
Zaretskaya, Yu.M. and Abramov, V.Yu., Novye antigeny tkanevoi sovmestimosti cheloveka (New Antigens of Human Tissue Compatibility), Moscow: Meditsyna, 1986.
Technical Manual, American Association of Blood, 1996, 12th ed.
Rumyantsev, A.G. and Agranenko, V.A., Klinicheskaya transfuziologiya (Clinical Transfusiology), Moscow: Geotar Meditsina, 1997.
Shabalin, V.N. and Serova, L.D., Klinicheskaya immunogematologiya (Clinical Immunohematology), Leningrad: Meditsyna, 1988.
Nersisyan, V.M., Martirosyan, I.G., and Musaelyan, N.O., A Population Study of the HLA-A, HLA-B, HLA-C, and HLA-DR Gene Frequencies in People Living in Armenia, Immunologiya, 1992, no. 1, pp. 25-28.
Akopyan, A.V., HLA Genetic Markers and Predisposition to Periodical Sickness in Armenians, Abstracts of Cand. Sci. Dissertation, Moscow, 1993.
Akopyan, A.V., Alekseev, L.P., and Khaitov, R.M., Specific Features of the Allele and Genotype Frequency Distributions of HLA Classes I, II, and III in the Armenian Population, Immunologiya, 1998, no. 1, pp. 11-12.
Pospelov, L.E., Malenko, A.F., Karapetyan, E.T., and Nikolayan, L.T., Histocompatibility Antigens in Ethnic Armenians with or without Tuberculosis, Eksp. Klinich. Medits. AN SSSR (Yerevan), 1987, no. 5, pp. 479-482.
Zaretskaya, Yu.M., Klinicheskaya immunogenetika (Clinical Immunogenetics), Moscow: Meditsina, 1983.
Aiala, F., Vvedenie v populyatsionnuyu i evolyutsionnuyu genetiku (Introduction to Population and Evolutionary Genetics), Moscow: Mir, 1984.
Enstroth, A.F., Mann, D.L., Johnson, A.H., et al., HLA and B-Lymphocyte Alloantigens in Gila River Indians, Tissue Antigens, 1983, vol. 21, no. 3, p. 198.
Alekseev, A.P., Mkhatadze, N.I., Yazdovskii, V.V., and Meunargia, V.V., A Population Study of the HLA Gene and Haplotype Frequencies in Ethnic Georgians, Immunologiya, 1986, no. 6, pp. 15-17.
Ragimov, A.A., Kalinichenko, A.G., and Ovcharenko, M.D., Antigen, Gene, and Haplotype Frequency Distributions of the HLA System in Azerbaijani from Baku, I Respulikanskii s''ezd gematologov i transfuziologov Gruzii (I Rep. Meet. of Hematologists and Transfusiologists of Georgia), Tbilisi, 1983, pp. 201-203.
Bodmer, W., The HLA-System, Histocompatibility Testing, Albert, E., et al., Eds., Berlin, 1984, p. 11.
Mori, M., Beatty, P., Graves, M., et al., HLA Gene and Haplotype Frequencies in the North American Population: The National Marrow Donor Program Donor Registry, Transplantation, 1997, vol. 64, no. 7, pp. 1017-1027.
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Nersisyan, V.M., Martirosyan, I.G., Musaelyan, N.O. et al. Distribution of HLA Antigens in the Armenian Population of Nagornyi Karabakh. Russian Journal of Genetics 38, 843–846 (2002). https://doi.org/10.1023/A:1016360209460
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DOI: https://doi.org/10.1023/A:1016360209460