Abstract
Several 6-chloro-5-nitropyrimidines were synthesized, and their antifungal activity was tested. Some derivatives were equipotent or superior to amphotericin B in vitro but their relatively high toxicity in mice and their chemical instability discourage further evaluation.
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McChesney, J.D., Gonzalez-Sierra, M. Antifungal Activity of Some Substituted Pyrimidines. Pharm Res 2, 146–147 (1985). https://doi.org/10.1023/A:1016323702665
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DOI: https://doi.org/10.1023/A:1016323702665