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Simultaneous Determination of Tiaramide and its Metabolites by High Performance Liquid Chromatography

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Abstract

A simultaneous quantitative HPLC assay was developed for tiaramide hydrochloride (4-[(5-chloro-2-oxo-3(2H)-benzothiazolyl) acetyl]-1-piperazine ethanol hydrochloride) and its main metabolites, namely, 1 - [ (5-chloro-2-oxo-3 (2H) -benzothiazolyl) -acetyl]-piperazine (DETR) and 4-[(5-chloro-2-oxo-3(2H)-benzothiazolyl) acetyl] -piperazine acetic acid (TRAA). The assay was employed to determine plasma levels of tiaramide and its main metabolite, TRAA, after intravenous administration of tiaramide hydrochloride to rabbits.

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Authors and Affiliations

  1. Department of Pharmacy, Kyoto College of Pharmacy, Misasagi, Yamashina-ku, Kyoto, 607, Japan

    Shun-ichi Naito

Authors
  1. Shun-ichi Naito
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  2. Atsushi Tanase
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  3. Hisao Yoshihara
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  4. Hideharu Tominaga
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Naito, Si., Tanase, A., Yoshihara, H. et al. Simultaneous Determination of Tiaramide and its Metabolites by High Performance Liquid Chromatography. Pharm Res 2, 140–142 (1985). https://doi.org/10.1023/A:1016319501756

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  • DOI: https://doi.org/10.1023/A:1016319501756

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