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Phosphinic Acid Analogues of Methylaspartic and Methylglutamic Acids as Antibacterials

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Abstract

DL-l-Amino-l-methyl-3-carboxypropanephosphinic acid, a bioisostere of α-methylglutamic acid, was synthesized. This compound, the corresponding α-methylaspartic acid analogue and their precursors were tested for antibacterial activity. The methylaspartic acid analogue gave a MIC of 400 and 800 µg/ml against B. subtilis and P. aeroginosa, respectively.

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Authors and Affiliations

  1. Department of Medicinal Chemistry, College of Pharmacy, University of Houston – University Park, Houston, TX, 77004

    Lindley A. Cates

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  1. Lindley A. Cates
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  2. Ven-Shun Li
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Cates, L.A., Li, VS. Phosphinic Acid Analogues of Methylaspartic and Methylglutamic Acids as Antibacterials. Pharm Res 2, 135–136 (1985). https://doi.org/10.1023/A:1016315400847

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