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Pharmaceutical Research

, Volume 3, Issue 5, pp 253–262 | Cite as

The Bioavailability of Dermatological and Other Topically Administered Drugs

  • Richard H. Guy
  • Anna H. Guy
  • Howard I. Maibach
  • Vinod P. Shah
Article

Abstract

The literature addressing determination of the bioavailability of dermatological and other topically administered drugs has been reviewed. The various methods employed, their advantages and drawbacks, have been identified and evaluated. The state of the art and the success of topical bioavailability assessment are discussed in the light of the information presented. It is concluded that, although current methodology ensures the responsible use of topical medicaments, the techniques are, on the whole, quantitatively inadequate. A number of recommendations are proposed as possible improvements to the approaches now undertaken, and specific measurements for drugs in different therapeutic categories are suggested. The ultimate objective of this survey is to catalyze the establishment of straightforward, objective, quantitative, and reproducible methods to evaluate topical bioavailability and to reduce significantly, thereby, the incidence of bioinequivalence and pharmacological inactivity observed following drug dosing to the skin.

topical drugs, bioavailability percutaneous absorption pharmacology, cutaneous bioequivalence, topical 

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REFERENCES

  1. 1.
    B. W. Barry. Pharm J. 215:322–325 (1975).Google Scholar
  2. 2.
    B. W. Barry. Dermatologica 152:47–65 (1976).Google Scholar
  3. 3.
    B. W. Barry. Dermatological Formulations: Percutaneous Absorption, Marcel Dekker, New York, 1983.Google Scholar
  4. 4.
    H. Schaefer, A. Zesch, and G. Stuttgen. Skin Permeability, Springer-Verlag, Berlin, 1982.Google Scholar
  5. 5.
    M. Katz. In E. J. Ariens (ed.), Drug Design IV, Marcel Dekker, New York, 1973, pp. 93–148.Google Scholar
  6. 6.
    M. Katz and M. K. Polano. J. Soc. Cosmet. Chem. 23:565–590 (1972).Google Scholar
  7. 7.
    B. J. Poulsen. In E. J. Ariens (ed.), Drug Design IV, Academic Press, London, 1973, pp. 150–192.Google Scholar
  8. 8.
    B. W. Barry. In R. L. Bronaugh and H. I. Maibach (eds.), Percutaneous Absorption, Marcel Dekker, New York, 1985, pp. 489–511.Google Scholar
  9. 9.
    R. C. Wester and H. I. Maibach. Drug Metab. Rev. 14:169–205 (1983).Google Scholar
  10. 10.
    H. Baker. J. Soc. Cosmet. Chem. 20:239–252 (1969).Google Scholar
  11. 11.
    J. W. Hadgraft. J. Mond. Pharm. 3:309–321 (1967).Google Scholar
  12. 12.
    J. W. Hadgraft. Br. J. Dermatol. 87:386–389 (1972).Google Scholar
  13. 13.
    S. L. Yankell. Adv. Biol. Skin 12:511–522 (1972).Google Scholar
  14. 14.
    J. W. Hadgraft and I. Sarkany. Br. J. Clin. Pract. 22:455–456 (1968).Google Scholar
  15. 15.
    T. Higuchi. J. Soc. Cosmet. Chem. 11:85–97 (1960).Google Scholar
  16. 16.
    T. Higuchi. J. Pharm Sci. 50:874–875 (1961).Google Scholar
  17. 17.
    B. Idson. Drug Metab. Rev. 14:207–222 (1983).Google Scholar
  18. 18.
    B. C. Lippold. Pharm. Acta Helv. 59:166–171 (1984).Google Scholar
  19. 19.
    B. J. Poulsen. Br. J. Dermatol. 82:49–52 (1970).Google Scholar
  20. 20.
    B. J. Poulsen. Adv. Biol. Skin 12:495–509 (1972).Google Scholar
  21. 21.
    M. J. Busse, P. Hunt, K. A. Lees, P. N. D. Maggs, and J. M. McCarthy, Br. J. Dermatol. 81:103–112 (1969).Google Scholar
  22. 22.
    G. A. Christie and M. Moore-Robinson. Br. J. Dermatol. 82:93–98 (1970).Google Scholar
  23. 23.
    J. Ostrenga, C. Steinmetz, B. Poulsen, and S. Yett. J. Pharm. Sci. 60:1180–1183 (1971).Google Scholar
  24. 24.
    M. C. Poelman, J. L. Leveque, and F. LeGall. Br. J. Dermatol. 27:158–162 (1984).Google Scholar
  25. 25.
    E. R. Cooper. In R. L. Bronaugh and H. I. Maibach (eds.), Percutaneous Absorption, Marcel Dekker, New York, 1985, pp. 525–529.Google Scholar
  26. 26.
    C. L. Gummer. In R. L. Bronaugh and H. I. Maibach (eds.), Percutaneous Absorption, Marcel Dekker, New York, 1985, pp. 561–570.Google Scholar
  27. 27.
    S. K. Chandrasekaran and J. E. Shaw. Curr. Probl. Dermatol. 7:142–155 (1978).Google Scholar
  28. 28.
    P. Grasso and A. B. G. Landsdowne. J. Soc. Cosmet. Chem. 23:481 (1972).Google Scholar
  29. 29.
    B. Idson. J. Pharm. Sci. 64:901–924 (1975).Google Scholar
  30. 30.
    M. Katz and B. J. Poulsen. In B. B. Brodie and J. Gillette (eds.), Handbook of Experimental Pharmacology. New Series XXVII/2, Springer-Verlag, Berlin, 1971, pp. 103–174.Google Scholar
  31. 31.
    S. Riegelman. Clin. Pharmacol. Ther. 16:873–883 (1974).Google Scholar
  32. 32.
    H. Schaefer, G. Stuttgen, W. Schalla, J. Gazith, and E. Bauer. Adv. Pharm. Ther. 9:223–235 (1978).Google Scholar
  33. 33.
    W. Schalla, and H. Schaefer. In R. Brandau and B. J. Lippold (eds.), Dermal & Transdermal Absorption, Wissenschaftliche Verlagsgesellschaft mbh, Stuttgart, 1981, pp. 41–72.Google Scholar
  34. 34.
    R. J. Scheuplein. Curr. Probl. Dermatol. 7:172–186 (1978).Google Scholar
  35. 35.
    R. B. Stoughton. In T. H. Sternberg and V. D. Newcomer (eds.), Evaluation of Therapeutic Agents and Cosmetics, McGraw-Hill, New York, 1964, pp. 25–35.Google Scholar
  36. 36.
    R. B. Stoughton. Dermatologica 152:27–56 (1976).Google Scholar
  37. 37.
    D. E. Wurster. Curr. Probl. Dermatol. 7:156–171 (1978).Google Scholar
  38. 38.
    A. M. Kligman. Drug Dev. Ind. Pharm. 9:521–560 (1983).Google Scholar
  39. 39.
    S. K. Chandrasekaran, W. Bayne, and J. E. Shaw. J. Pharm. Sci. 67:1370–1374 (1978).Google Scholar
  40. 40.
    E. R. Cooper, J. Pharm. Sci. 65:1396–1397 (1976).Google Scholar
  41. 41.
    R. H. Guy, J. Hadgraft, and H. I. Maibach. Toxicol. Appl. Pharmacol. 78:123–129 (1985).Google Scholar
  42. 42.
    R. H. Guy, and J. Hadgraft. J. Control. Rel. 1:177–182 (1985).Google Scholar
  43. 43.
    R. C. Wester, P. K. Noonan, S. Smeach, and L. Kosobud. J. Pharm. Sci. 72:745–748 (1983).Google Scholar
  44. 44.
    A. H. Beckett, J. W. Gorrod, and D. C. Taylor. J. Pharm. Pharmacol. 24:65–70 (1972).Google Scholar
  45. 45.
    C. Muir and R. Metcalfe. J. Pharm. Biomed. Anal. 1:363–367 (1983).Google Scholar
  46. 46.
    P. H. Vlasses, L. G. T. Ribeiro, H. H. Rotmensch, J. V. Bondi, A. E. Loper, M. Hichens, M. C. Dunlay, and R. K. Ferguson. J. Cardiovasc. Pharmacol. 7:245–250 (1985).Google Scholar
  47. 47.
    T. R. MacGregor, K. M. Matzek, J. J. Keirns, R. G. A. Van Wayjen, A. van den Ende, and R. G. L. van Tol. Clin. Pharmacol. Ther. 38:278–284 (1985).Google Scholar
  48. 48.
    L. R. Laufer, J. L. DeFazio, J. K. H. Lu, D. R. Meldrum, P. Eggena, M. P. Sambhi, J. M. Hershman, and J. L. Judd. Am. J. Obstet. Gynecol. 146:533–540 (1983).Google Scholar
  49. 49.
    P. R. Imhof, T. Vuillemin, A. Gerardin, A. Racine, P. Muller, and F. Follath. Eur. J. Clin. Pharmacol. 27:7–12 (1984).Google Scholar
  50. 50.
    R. C. Wester and P. K. Noonan. J. Invest. Dermatol. 70:92–94 (1978).Google Scholar
  51. 51.
    R. J. Feldmann and H. I. Maibach. J. Invest. Dermatol. 48:181–183 (1967).Google Scholar
  52. 52.
    R. J. Feldmann and H. I. Maibach. J. Invest. Dermatol. 52:89–94 (1969).Google Scholar
  53. 53.
    R. J. Feldmann and H. I. Maibach. J. Invest. Dermatol. 54:339–404 (1969).Google Scholar
  54. 54.
    H. I. Maibach and R. J. Feldman. J. Invest Dermatol. 52:381–386 (1969).Google Scholar
  55. 55.
    H. I. Maibach, R. J. Feldmann, T. H. Milby, and W. F. Serat, Arch. Environ. Health 23:208–211 (1971).Google Scholar
  56. 56.
    R. J. Feldmann and H. I. Maibach. Toxicol. Appl. Pharmacol. 28:120–132 (1974).Google Scholar
  57. 57.
    R. J. Feldmann and H. I. Maibach. Arch. Dermatol. 109:58–59 (1974).Google Scholar
  58. 58.
    T. J. Franz. Arch. Dermatol. 121:203–206 (1985).Google Scholar
  59. 59.
    H. I. Maibach, M. A. Leaffer, and W. A. Skinner. Arch. Dermatol. 111:1444–1445 (1975).Google Scholar
  60. 60.
    F. N. Marzulli, D. M. Anjo, and H. I. Maibach. Food Cosmet. Toxicol. 19:743–747 (1981).Google Scholar
  61. 61.
    S. Nacht, D. Yeung, J. N. Beasley, D. M. Anjo, and H. I. Maibach. J. Am Acad. Dermatol. 4:31–37 (1981).Google Scholar
  62. 62.
    D. A. W. Bucks. Pharm. Res. 1:148–153 (1984).Google Scholar
  63. 63.
    P. K. Noonan and R. C. Wester. In R. L. Bronaugh and H. I. Maibach (eds.), Percutaneous Absorption, Marcel Dekker, New York, 1985, pp. 65–85.Google Scholar
  64. 64.
    R. H. Guy and H. I. Maibach. J. Pharm. Sci. 72:1375–1380 (1983).Google Scholar
  65. 65.
    D. M. Anjo, R. J. Feldmann, and H. I. Maibach. In P. Mauvais-Jarvais, J. Wepierre, and C. F. H. Vickers (eds.), Percutaneous Penetration of Steroids, Academic Press, New York, 1980, pp. 31–51.Google Scholar
  66. 66.
    A. Rougier, D. Dupuis, C. Lotte, R. Roguet, and H. Schaefer. J. Invest. Dermatol. 81:275–278 (1983).Google Scholar
  67. 67.
    D. Dupuis, A. Rougier, R. Roguet, C. Lotte, and G. Kalopissis. J. Invest. Dermatol. 82:353–356 (1984).Google Scholar
  68. 68.
    A. Rougier, D. Dupuis, C. Lotte, and R. Roguet. J. Invest. Dermatol. 84:66–68 (1985).Google Scholar
  69. 69.
    R. C. Wester and H. I. Maibach. In H. I. Maibach and N. J. Lowe (eds.), Models in Dermatology, Vol 2, Karger, Basel, 1985, pp. 159–169.Google Scholar
  70. 70.
    R. C. Wester and H. I. Maibach. In R. L. Bronaugh and H. I. Maibach (eds.), Percutaneous Absorption, Marcel Dekker, New York, 1985, pp. 251–266.Google Scholar
  71. 71.
    K. E. Andersen, H. I. Maibach, and D. M. Anjo. Br. J. Dermatol 102:447–453 (1980).Google Scholar
  72. 72.
    M. J. Bartek, J. A. La Budde, and H. I. Maibach. J. Invest. Dermatol. 58:114–123 (1972).Google Scholar
  73. 73.
    M. J. Bartek and J. A. La Budde. In H. I. Maibach (ed.), Animal Models in Dermatology, Churchill Livingstone, New York, 1975, pp. 103–120.Google Scholar
  74. 74.
    R. L. Bronaugh, R. F. Stewart, and E. R. Congdon. Toxicol. Appl. Pharmacol. 62:481–488 (1982).Google Scholar
  75. 75.
    N. Hunziker, R. J. Feldmann, and H. I. Maibach. Dermatologica 156:79–88 (1978).Google Scholar
  76. 76.
    F. N. Marzulli, D. W. C. Brown, and H. I. Maibach. Toxicol. Appl. Pharmacol. 3:79–83 (1969).Google Scholar
  77. 77.
    A. H. McGreesh. Toxicol. Appl. Pharmacol. 2:20–26 (1965).Google Scholar
  78. 78.
    R. T. Tregear. Physical Functions of Skin, Academic Press, New York, 1966.Google Scholar
  79. 79.
    W. G. Reifenrath, E. M. Chellquist, E. A. Shipwash, and W. W. Jederberg. Fund. Appl. Toxicol. 4:S224–S230 (1984).Google Scholar
  80. 80.
    W. G. Reifenrath, E. M. Chellquist, E. A. Shipwash, W. W. Jederberg, and G. G. Krueger. Br. J. Dermatol. 111:123–135 (1984).Google Scholar
  81. 81.
    R. C. Wester and H. I. Maibach. Toxicol. Appl. Pharmacol. 32:394–398 (1975).Google Scholar
  82. 82.
    R. C. Wester and H. I. Maibach. In H. I. Maibach (ed.), Animal Models in Dermatology, Churchill-Livingstone, New York, 1975, pp. 133–137.Google Scholar
  83. 83.
    R. C. Wester and H. I. Maibach. J. Invest. Dermatol. 67:518–520 (1976).Google Scholar
  84. 84.
    R. C. Wester and H. I. Maibach. In V. Drill and P. Lazar (eds.), Cutaneous Toxicity, Academic, New York, 1977, pp. 111–126.Google Scholar
  85. 85.
    R. C. Wester and P. K. Noonan. J. Invest. Dermatol. 70:92–94 (1978).Google Scholar
  86. 86.
    R. C. Wester and P. K. Noonan. Int. J. Pharm. 7:99–110 (1980).Google Scholar
  87. 87.
    R. C. Wester, P. K. Noonan, M. P. Cole, and H. I. Maibach. Pediat. Res. 11:737–739 (1977).Google Scholar
  88. 88.
    R. C. Wester, P. K. Noonan, and H. I. Maibach. Arch. Dermatol. 113:620–622 (1977).Google Scholar
  89. 89.
    R. C. Wester, P. K. Noonan, and H. I. Maibach. J. Soc. Cosmet. Chem. 30:297–307 (1979).Google Scholar
  90. 90.
    R. C. Wester, P. K. Noonan, and H. I. Maibach. Arch. Dermatol. Res. 267:229–235 (1980).Google Scholar
  91. 91.
    R. C. Wester, P. K. Noonan, and H. I. Maibach. Arch. Dermatol. 116:186–188 (1980).Google Scholar
  92. 92.
    R. L. Bronaugh. In R. L. Bronaugh and H. I. Maibach (eds.), Percutaneous Absorption, Marcel Dekker, New York, 1985, pp. 267–279.Google Scholar
  93. 93.
    B. J. Poulsen and G. L. Flynn. In R. L. Bronaugh and H. I. Maibach (eds.), Percutaneous Absorption, Marcel Dekker, New York, 1985, pp. 431–459.Google Scholar
  94. 94.
    J. Houk and R. H. Guy. Submitted for publication.Google Scholar
  95. 95.
    R. L. Bronaugh, E. R. Congdon, and R. J. Scheuplein. J. Invest. Dermatol. 76:94–96 (1981).Google Scholar
  96. 96.
    R. L. Bronaugh and R. F. Stewart. J. Pharm. Sci. 75:487–491 (1986).Google Scholar
  97. 97.
    T. J. Franz. J. Invest. Dermatol. 64:190–195 (1975).Google Scholar
  98. 98.
    T. J. Franz. Curr. Probl. Dermatol. 7:58–68 (1978).Google Scholar
  99. 99.
    R. J. Scheuplein, I. H. Blank, G. J. Brauner, and D. J. MacFarlane. J. Invest. Dermatol. 52:63–70 (1969).Google Scholar
  100. 100.
    H. Schaefer and W. Schalla. In P. Mauvais-Jarvais, J. Wepierre, and C. F. H. Vickers (eds.), Percutaneous Penetration of Steroids, Academic Press, New York, 1980, pp. 53–67.Google Scholar
  101. 101.
    A. Hoelgaard and B. Mollgaard. J. Control. Rel. 2:111–120 (1985).Google Scholar
  102. 102.
    K. Knutson, R. O. Potts, D. B. Guzek, G. M. Golden, J. E. McKie, W. J. Lambert, and W. I. Higuchi. J. Control. Rel. 2:67–87 (1985).Google Scholar
  103. 103.
    A. S. Michaels, S. K. Chandrasekaran, and J. E. Shaw. AIChE J. 21:985–996 (1975).Google Scholar
  104. 104.
    R. J. Scheuplein. In P. Mauvais-Jarvais, C. F. H. Vickers, and J. Wepierre (eds.), Percutaneous Penetration of Steroids, Academic Press, New York, 1980, pp. 1–17.Google Scholar
  105. 105.
    R. J. Scheuplein. J. Invest. Dermatol. 45:334–346 (1965).Google Scholar
  106. 106.
    S. Grayson and P. M. Elias. J. Invest. Dermatol. 78:128–135 (1982).Google Scholar
  107. 107.
    P. M. Elias. Int. J. Dermatol. 20:1–19 (1981).Google Scholar
  108. 108.
    E. Menczel, D. A. W. Bucks, R. C. Wester, and H. I. Maibach. In R. L. Bronaugh and H. I. Maibach (eds.), Percutaneous Absorption, Marcel Dekker, New York, 1985, pp. 43–56.Google Scholar
  109. 109.
    L. B. Fisher. In R. L. Bronaugh and H. I. Maibach (eds.), Percutaneous Absorption, Marcel Dekker, New York, 1983, pp. 213–222.Google Scholar
  110. 110.
    R. C. Wester and H. I. Maibach. In W. R. Hunt, M. K. Schmidt, and D. Worth (eds.), Environmental Factors in Human Growth and Development, Cold Spring Harbor Press, Cold Spring Harbor, N.Y., 1982, pp. 3–15.Google Scholar
  111. 111.
    J. J. McCormack, E. K. Boisits, and L. B. Fisher. In H. I. Maibach and E. K. Boisits (eds.), Neonatal Skin: Structure and Function, Marcel Dekker, New York, 1982, pp. 149–164.Google Scholar
  112. 112.
    V. A. Harpin and N. Rutter. J. Pediat. 102:419–425 (1983).Google Scholar
  113. 113.
    D. R. Wilson and H. I. Maibach. In H. I. Maibach and E. K. Boisits (eds.), Neonatal Skin: Structure and Function, Marcel Dekker, New York, 1982, pp. 101–110.Google Scholar
  114. 114.
    E. Christophers and A. M. Kligman. In W. Montagna (ed.), Advances in Biology of Skin. Vol. VI. Aging, Pergamon Press, New York, 1964, pp. 163–175.Google Scholar
  115. 115.
    H. Tagami. Acta Dermatol. (Kyoto) 66:19–21 (1971).Google Scholar
  116. 116.
    A. M. Kligman. J. Invest. Dermatol. 73:39–46 (1979).Google Scholar
  117. 117.
    R. R. Kohn. Proc. Soc. Exp. Biol. Med. 131:521–522 (1969).Google Scholar
  118. 118.
    R. H. Guy, E. Tur, S. Bjerke, and H. I. Maibach. J. Am. Acad. Dermatol. 12:1001–1006 (1985).Google Scholar
  119. 119.
    B. A. Gilchrest. Skin and Aging Processes, CRC Press, Boca Raton, Fla., 1984.Google Scholar
  120. 120.
    D. Southwell and B. W. Barry. J. Invest. Dermatol. 80:507–514 (1983).Google Scholar
  121. 121.
    S. A. Akhter and B. W. Barry. J. Pharm. Pharmacol. 37:27–37 (1985).Google Scholar
  122. 122.
    B. W. Barry, D. Southwell, and R. Woodford. J. Invest. Dermatol. 82:49–52 (1984).Google Scholar
  123. 123.
    S. L. Bennett, B. W. Barry, and R. Woodford. J. Pharm. Pharmacol. 37:570–576 (1985).Google Scholar
  124. 124.
    R. B. Stoughton. Arch. Dermatol. 118:474–477 (1982).Google Scholar
  125. 125.
    R. B. Stoughton and W. O. McClure. Drug Dev. Ind. Pharm. 9:725–744 (1983).Google Scholar
  126. 126.
    D. S.-L. Chow, I. Kaka, and T. I. Wang. J. Pharm. Sci. 73:1794–1797 (1984).Google Scholar
  127. 127.
    S. L. Spruance, M. McKeough, K. Sugibayashi, F. Robertson, P. Gaede, and D. S. Clark. Antimicrob. Agents Chemother. 26:819–823 (1984).Google Scholar
  128. 128.
    P. K. Wotton, B. Mollgaard, J. Hadgraft, and A. Hoelgaard. Int. J. Pharm. 24:19–26 (1985).Google Scholar
  129. 129.
    R. O. Potts. J. Soc. Cosmet. Chem. 37:9–33 (1986).Google Scholar
  130. 130.
    R. C. Cornell and R. B. Stoughton. Arch. Dermatol. 121:63–67 (1985).Google Scholar
  131. 131.
    J. M. Haigh and I. Kanfer. Int. J. Pharm. 19:245–262 (1984).Google Scholar
  132. 132.
    A. W. McKenzie and R. B. Stoughton. Arch. Dermatol. 86:608–610 (1962).Google Scholar
  133. 133.
    V. Place, J. G. Velazquez, and K. H. Burdick. Arch. Dermatol. 101:531–537 (1970).Google Scholar
  134. 134.
    B. J. Poulsen, K. Burdick, and S. Bessler. Arch. Dermatol. 109:367–371 (1974).Google Scholar
  135. 135.
    R. B. Stoughton. Arch. Dermatol. 99:753–756 (1969).Google Scholar
  136. 136.
    R. B. Stoughton. Arch. Dermatol. 106:825–827 (1972).Google Scholar
  137. 137.
    R. Woodford and B. W. Barry. J. Invest. Dermatol. 79:388–391 (1982).Google Scholar
  138. 138.
    R. Woodford and B. W. Barry. Acta Pharm. Suecica 20:53 (1983).Google Scholar
  139. 139.
    R. H. Guy, E. Tur, H. I. Maibach. Int. J. Derm. 24:88–94 (1985).Google Scholar
  140. 140.
    N. M. Price, L. G. Schmitt, J. McGuire, J. E. Shaw, and G. Trobough. Clin. Pharmacol. Ther. 29:414–419 (1981).Google Scholar
  141. 141.
    S. K. Chandrasekaran. Drug Dev. Ind. Pharm. 9:627–646 (1983).Google Scholar
  142. 142.
    P. Muller, P. R. Imhof, F. Burkart, L.-C. Chu, and A. Gerardin. Eur. Clin. Pharmacol. 22:473–480 (1982).Google Scholar
  143. 143.
    P. R. Imhof. In L. F. Prescott and W. S. Nimmo (eds.), Rate Control in Drug Therapy, Churchill Livingstone, Edinburgh, 1985, pp. 201–214.Google Scholar
  144. 144.
    A. Karim. Angiology 34:11–21 (1983).Google Scholar
  145. 145.
    W. R. Good. Drug. Dev. Ind. Pharm. 9:647–670 (1983).Google Scholar
  146. 146.
    M. Wolff, G. Cordes, and V. Luckow. Pharm. Res. 2:23–29 (1985).Google Scholar
  147. 147.
    D. Arndts and K. Arndts. Eur. J. Clin. Pharmacol. 26:79–85 (1984).Google Scholar
  148. 148.
    A. A. H. Lawson. In L. F. Prescott and W. S. Nimmo (eds.), Rate Control in Drug Therapy, Churchill Livingstone, Edinburgh, 1985, pp. 215–219.Google Scholar
  149. 149.
    M. Hollenberg and M. Go. Am. Heart J. 108:223–231 (1984). (1984).Google Scholar
  150. 150.
    S. Scheidt. Am. J. Cardiol. 56:31–71 (1985).Google Scholar
  151. 151.
    “In Vitro Percutaneous Penetration,” a workshop cosponsored by FDA and AAPS, Oct.–Nov. 1986, Washington, D.C.Google Scholar
  152. 152.
    W. L. Epstein, V. P. Shah, and S. Riegelman. Arch. Dermatol. 106:344–348 (1972).Google Scholar
  153. 153.
    W. L. Epstein, V. Shah, and S. Riegelman. Cutis 15:271–276 (1975).Google Scholar
  154. 154.
    W. L. Epstein, V. P. Shah, H. E. Jones, and S. Riegelman. Arch. Dermatol. 111:1293–1297 (1975).Google Scholar
  155. 155.
    S. M. Wallace, V. P. Shah, W. L. Epstein, J. Greenberg, and S. Riegelman. Arch. Dermatol. 113:1539–1542 (1977).Google Scholar
  156. 156.
    H. Schaefer, G. Stuttgen, A. Zesch, W. Schalla, and J. Gazith. Curr. Probl. Dermatol. 7:80–94 (1978).Google Scholar
  157. 157.
    W. Schalla and H. Schaefer. In R. L. Bronaugh and H. I. Maibach (eds.), Percutaneous Absorption, Marcel Dekker, New York, 1985, pp. 281–303.Google Scholar
  158. 158.
    A. G. Knight. Br. J. Dermatol. 91:49–55 (1974).Google Scholar
  159. 159.
    T. Fischer and H. I. Maibach. Cont. Derm. 11:285–287 (1984).Google Scholar
  160. 160.
    T. Fischer and H. I. Maibach. Cont. Derm. 11:134 (1984).Google Scholar
  161. 161.
    T. Fischer and H. I. Maibach. Cont. Derm. 11:224–228 (1984).Google Scholar
  162. 162.
    K. S. Ryatt, J. W. Feather, A. Mehta, J. B. Dawson, J. A. Cotterill, and R. Swallow. Br. J. Dermatol. 107:71–76 (1982).Google Scholar
  163. 163.
    M. J. Busse. Pharm. J. 220:25–26 (1978).Google Scholar
  164. 164.
    K. H. Burdick, B. J. Poulsen, and V. A. Place. JAMA 211:462–466 (1970).Google Scholar
  165. 165.
    J. R. Gibson, C. Darley, J. Kirsch, E. M. Saihan, and V. S. Neild. Br. J. Dermatol. 106:445–448 (1982).Google Scholar
  166. 166.
    J. R. Gibson, J. Kirsch, C. R. Darley, and C. A. Burke. Br. J. Dermatol. 109:114–116 (1983).Google Scholar
  167. 167.
    J. M. Kirsch, J. R. Gibson, and C. R. Darley. Br. J. Dermatol. 108:250–252 (1983).Google Scholar
  168. 168.
    J. M. Kirsch, J. R. Gibson, C. R. Darley, and C. A. Burke. Dermatologica 167:138–141 (1983).Google Scholar
  169. 169.
    O. H. Mills and A. M. Kligman. Hawaii. Med. J. 41:416–420 (1982).Google Scholar
  170. 170.
    R. J. Orr, N. C. Lacina, L. S. Peters, and G. L. Flynn. Am. Pharm. NS18:23–26 (1978).Google Scholar
  171. 171.
    M. C. Smith, A. H. Kibbe, and T. R. Brown. J. Am. Acad. Dermatol. 11:148–151 (1984).Google Scholar
  172. 172.
    C. W. Barrett, J. W. Hadgraft, G. A. Caron, and I. Sarkany. Br. J. Dermatol. 77:576–578 (1965).Google Scholar

Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • Richard H. Guy
    • 1
  • Anna H. Guy
    • 1
  • Howard I. Maibach
    • 2
  • Vinod P. Shah
    • 3
  1. 1.Departments of Pharmacy & Pharmaceutical Chemistry, School of PharmacyUniversity of CaliforniaSan Francisco
  2. 2.Department of Dermatology, School of MedicineUniversity of CaliforniaSan Francisco
  3. 3.Division of BiopharmaceuticsFood & Drug AdministrationRockville

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