Skip to main content

Pine Resin and Biopin Ointment: Immunotoxic and Allergenic Activity

Abstract

We studied properties of ointment Biopin containing pine resin and used for the therapy of burns, wounds, and purulent and inflammatory diseases. Long-term treatment with this preparation in clinical doses had no effect on the nonspecific, but modulated the specific immune response. Biopin ointment inhibited humoral, but stimulated cell immunity. Neither local irritation, nor allergic reactions were found after long-term epicutaneous application of the preparation.

This is a preview of subscription content, access via your institution.

REFERENCES

  1. Methodical Recommendations for Estimating Allergenic Properties of Pharmacological Preparations [in Russian], Moscow (1988).

  2. Methodical Recommendations for Estimating Immunotoxic Properties of Pharmacological Preparations [in Russian], Moscow (1992).

  3. V. M. Nikitin, Manual on Immunological Methods [in Russian], Kishinev (1982).

  4. B. A. Paramonov and G. Sh. Mchedlidze, Therapy of Burns, Wounds, and Trophic Ulcers by Ointment Biopin [in Russian], St. Petersburg (2001).

  5. B. A. Paramonov, Ya. O. Porembskii, and V. G. Yablonskii, Burns: Manual for Physicians [in Russian], St. Petersburg (2000).

  6. S. V. Suvorov, Prevention of Occupational Skin Diseases in Railway Workers as the Complex Hygienic Problem [in Russian], Moscow (1974).

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to V. Yu. Chebotarev.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Simbirtsev, A.S., Konusova, V.G., Mchedlidze, G.S. et al. Pine Resin and Biopin Ointment: Immunotoxic and Allergenic Activity. Bulletin of Experimental Biology and Medicine 133, 384–385 (2002). https://doi.org/10.1023/A:1016258323713

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1016258323713

  • pine resin
  • Biopin ointment
  • nonspecific immunity
  • specific immunity
  • allergic effect