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Enzymatic resolution of amino acid esters using ionic liquid N-ethyl pyridinium trifluoroacetate

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Abstract

A new ionic liquid, N-ethyl pyridinium trifluoroacetate, was used with a commercial protease to resolve N-acetyl amino acid esters in place of traditional organic solvents. Products with enantiomeric excess (ee) between 86–97% were obtained. These results show that with low concentration of this new ionic liquid, the enzymatic resolution can be increased considerably depending upon the substrate being used.

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Authors and Affiliations

  1. Department of Chemistry and Environmental Science, New Jersey Institute of Technology, University Heights, Newark, NJ, 07102, USA

    Hua Zhao & Sanjay V. Malhotra

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  1. Hua Zhao
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  2. Sanjay V. Malhotra
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Zhao, H., Malhotra, S.V. Enzymatic resolution of amino acid esters using ionic liquid N-ethyl pyridinium trifluoroacetate. Biotechnology Letters 24, 1257–1259 (2002). https://doi.org/10.1023/A:1016205924504

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  • DOI: https://doi.org/10.1023/A:1016205924504

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