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Anxiolytic and Anxiogenic Effects of Diazepam in Male Mice with Different Experience of Aggression

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Abstract

Effects of diazepam (0.5 mg/kg intraperitoneally) on aggressive and anxious behavior were studied on male C57Bl/6J mice with different experience of aggression. Diazepam reduced aggression in animals with previous 3- and 20-day experience of aggression, but the plus-maze test revealed an anxiogenic effect of this drug in the former group and anxiolytic effect in the latter group. It was hypothesized that previous aggression experience modified animal sensitivity to diazepam. The effect of the drug depends on psychoemotional status of experimental animals, and this status differs in male mice with short- and long-term experience of aggression.

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REFERENCES

  1. S. F. De Boer, M. Lesourd, E. Mocaer, and J. M. Koolhaas, J. Pharmacol. Exp. Ther., 288, No. 3, 1125–1133(1999).

    Google Scholar 

  2. D. R. Cherek, F. G. Moeller, F. Khan-Dawood, et al., Psychopharmacology, 142, No. 2, 144–148(1999).

    Google Scholar 

  3. D. R. Cherek, J. L. Steinberg, T. H. Kelly, et al., Ibid.,100, No. 2, 173–181(1990).

    Google Scholar 

  4. D. F. Connor and R. J. Steingard, Ann. N. Y. Acad. Sci., No. 794, 290–307(1996).

    Google Scholar 

  5. A. Ferreira, O. Picazo, N. Uriarte, et al., Pharmacol. Biochem. Behav., 66, No. 2, 389–396(2000).

    Google Scholar 

  6. M. A. Hebert, M. Potegal, T. Moore, et al., Ibid., 55, No. 3, 405–413(1996).

    Google Scholar 

  7. M. Hillbrand and K. Scott, J. Autism. Dev. Disord., 25, No. 6, 663–664(1995).

    Google Scholar 

  8. R. Kavoussi, P. Armstead, and E. Coccaro, Psychiatr. Clin. North Am., 20, No. 2, 395–403(1997).

    Google Scholar 

  9. N. N. Kudryavtseva, Aggress. Behav., 17, No. 5, 285–291 (1991).

    Google Scholar 

  10. N. N. Kudryavtseva, Ibid.,26, 241–256(2000).

    Google Scholar 

  11. K. Pruus, T. Skrebuhhova-Malmros, R. Rudissaar, et al., J. Physiol. Pharmacol., 51, No. 4, Pt. 2, 833–846(2000).

    Google Scholar 

  12. R. J. Rodgers and J. C. Cole, Ethology and Psychopharmacology, Eds. S. J. Cooper et al., Chichester (1994), pp. 9–44.

  13. S. W. Stanislav, T. Fabre, M. L. Crismon, and A. Childs, J. Clin. Psychopharmacol., 14, No. 2, 126–130(1994).

    Google Scholar 

  14. S. M. White, R. F. Kucharik, and J. A. Moyer, Pharmacol. Biochem. Behav., 39, No. 3, 729–736(1991).

    Google Scholar 

  15. N. Wongwitdecha and C. A. Marsden, Behav. Brain Res., 75, No. 1–2, 27–32(1996).

    Google Scholar 

Download references

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Authors and Affiliations

  1. Sector of Social Behavior Neurogenetics, Institute of Cytology and genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk

    N. N. Kudryavtseva & N. P. Bondar'

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  1. N. N. Kudryavtseva
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  2. N. P. Bondar'
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Correspondence to N. N. Kudryavtseva.

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Kudryavtseva, N.N., Bondar', N.P. Anxiolytic and Anxiogenic Effects of Diazepam in Male Mice with Different Experience of Aggression. Bulletin of Experimental Biology and Medicine 133, 372–376 (2002). https://doi.org/10.1023/A:1016202205966

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