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A New Method for Diffusion Measurement in Polymeric Films Based on a Stacked Sheet Concept

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Abstract

Purpose. To develop and evaluate a simple, yet well defined, method to measure diffusion in semi-solids, i.e. polymeric materials.

Methods. The method was based on a concept where equivalent discs of polymeric films were cut and stacked on top of each other. The diffusion process was allowed to proceed unidimensionaly through the stack of films perpendicular to the film surface. After an appropriate time, the stack was analysed disc by disc with respect to solute content and from the concentration profile so obtained the diffusion coefficient was calculated.

Results. An all-in-one device was developed, manufactured in stainless-steel, that cuts circular discs and stores each one successively in a “stack” in the cell compartment.

Conclusions. Data from a silicone based system shows that the method, although simple, is accurate and reproducible.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, Physical and Inorganic Chemistry, Uppsala University, Box 574, Biomed, S-751 23, Uppsala, S, weden

    Hans Sjöberg & Lars-Olof Sundelöf

  2. Departement of Pharmaceutics, Pharmacia AB (publ), S-751 82, Uppsala, Sweden

    Rolf Bergman

Authors
  1. Hans Sjöberg
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  2. Rolf Bergman
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  3. Lars-Olof Sundelöf
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Sjöberg, H., Bergman, R. & Sundelöf, LO. A New Method for Diffusion Measurement in Polymeric Films Based on a Stacked Sheet Concept. Pharm Res 13, 1871–1874 (1996). https://doi.org/10.1023/A:1016097411615

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  • DOI: https://doi.org/10.1023/A:1016097411615

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